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阴茎鳞状细胞癌中原发肿瘤大小的预后意义。

The prognostic significance of primary tumor size in squamous cell carcinoma of the penis.

作者信息

Li Kai, Wu Guang, Fan Caibin, Yuan Hexing

机构信息

Department of Urology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, 26 Daoqian Road, Suzhou, 215000, Jiangsu Province, People's Republic of China.

Department of Urology, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou, 215000, Jiangsu Province, People's Republic of China.

出版信息

Discov Oncol. 2021 Jul 19;12(1):22. doi: 10.1007/s12672-021-00416-7.

DOI:10.1007/s12672-021-00416-7
PMID:35201454
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8777549/
Abstract

BACKGROUND

To evaluate the association of primary tumor size with clinicopathologic characteristics and survival of patients with squamous cell carcinoma of the penis (SCCP).

METHODS

This study analyzed the data of 1001 patients with SCCP, obtained from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database between 2010 and 2014. The Kaplan-Meier method and the Cox proportional hazards regression model were used to analyze the effects of primary tumor size on overall survival (OS) and penile carcinoma-specific survival (PCSS).

RESULTS

Advanced T stage (P < 0.001), lymph node metastasis (P < 0.001) and distant metastasis (P = 0.001) were more frequently associated with SCCP patients with tumor size ≥ 3 cm than those with tumor size  < 3 cm. In Kaplan-Meier analyses, the patients with large tumors (≥ 3 cm) exhibited an inferior OS and PCSS than those with small tumors (< 3 cm). Moreover, tumor size was identified to be an independent prognostic factor for OS [hazard ratio (HR) 1.665, P < 0.001] and PCSS (HR 2.076, P = 0.003) of patients with SCCP in multivariate analyses.

CONCLUSIONS

Large tumor size is associated with adverse clinicopathological characteristics of patients with SCCP. Besides, tumor size represents an independent prognostic factor for OS and PCSS. Therefore, clinical assessment of tumor size as a crucial prognostic factor might be highly beneficial for early intervention in patients with SCCP.

摘要

背景

评估阴茎鳞状细胞癌（SCCP）患者的原发肿瘤大小与临床病理特征及生存情况之间的关联。

方法

本研究分析了2010年至2014年期间从美国国立癌症研究所监测、流行病学和最终结果（SEER）数据库中获取的1001例SCCP患者的数据。采用Kaplan-Meier法和Cox比例风险回归模型分析原发肿瘤大小对总生存期（OS）和阴茎癌特异性生存期（PCSS）的影响。

结果

与肿瘤大小<3 cm的SCCP患者相比，肿瘤大小≥3 cm的SCCP患者更常出现晚期T分期（P<0.001）、淋巴结转移（P<0.001）和远处转移（P=0.001）。在Kaplan-Meier分析中，大肿瘤（≥3 cm）患者的OS和PCSS均低于小肿瘤（<3 cm）患者。此外，在多变量分析中，肿瘤大小被确定为SCCP患者OS[风险比（HR）1.665，P<0.001]和PCSS（HR 2.076，P=0.003）的独立预后因素。

结论

大肿瘤大小与SCCP患者不良的临床病理特征相关。此外，肿瘤大小是OS和PCSS的独立预后因素。因此，将肿瘤大小作为关键预后因素进行临床评估可能对SCCP患者的早期干预非常有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/fda71fb4c758/12672_2021_416_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/9b64c73349f8/12672_2021_416_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/4f016b53a6ac/12672_2021_416_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/181f94998562/12672_2021_416_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/4ef0b2573cf1/12672_2021_416_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/2b2368d1fa9d/12672_2021_416_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/ec32f90b70bd/12672_2021_416_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/f2ea34df8c47/12672_2021_416_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/1127b413cbfd/12672_2021_416_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/fda71fb4c758/12672_2021_416_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/9b64c73349f8/12672_2021_416_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/4f016b53a6ac/12672_2021_416_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/181f94998562/12672_2021_416_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/4ef0b2573cf1/12672_2021_416_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/2b2368d1fa9d/12672_2021_416_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/ec32f90b70bd/12672_2021_416_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/f2ea34df8c47/12672_2021_416_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/1127b413cbfd/12672_2021_416_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95b1/8777549/fda71fb4c758/12672_2021_416_Fig9_HTML.jpg

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