Compadre C M, Robbins E F, Kinghorn A D
J Ethnopharmacol. 1986 Jan;15(1):89-106. doi: 10.1016/0378-8741(86)90105-4.
Lippia dulcis Trev. (Verbenaceae) is the source of hernandulcin, the first known intensely sweet sesquiterpenoid, a compound which is a volatile oil constituent. The literature on the uses of this species, dating back to early colonial times in Mexico, has been examined. This plant began to be used as an official drug in the late 19th century for the treatment of coughs and bronchitis, and at that time preliminary phytochemical investigations were undertaken. Field work carried out in Mexico in 1981 and 1982 has indicated that there is still an active trade involving L. dulcis, which is sold primarily in market places for its alleged abortifacient activity. We have obtained no evidence, either from the literature or from field inquiries, that L. dulcis has ever been used for sweetening foods or beverages. Fourteen L. dulcis volatile oil constituents, mainly mono- and sesquiterpenoids, were identified by gas chromatography/mass spectrometry. The toxic compound, camphor, was found to constitute 53% w/w of the volatile oil of this species. The potential use of L. dulcis for the extraction of hernandulcin is discussed.
甜叶假荆芥（唇形科）是甜叶菊苷的来源，甜叶菊苷是已知的第一种强烈甜味倍半萜类化合物，是一种挥发油成分。对该物种用途的文献进行了研究，这些文献可追溯到墨西哥早期殖民时期。这种植物在19世纪后期开始被用作官方药物来治疗咳嗽和支气管炎，当时进行了初步的植物化学研究。1981年和1982年在墨西哥开展的实地调查表明，甜叶假荆芥仍有活跃的贸易，主要因其所谓的堕胎活性在市场上销售。无论是从文献还是实地调查中，我们都没有获得甜叶假荆芥曾被用于食品或饮料甜味剂的证据。通过气相色谱/质谱法鉴定出了14种甜叶假荆芥挥发油成分，主要是单萜和倍半萜类化合物。发现有毒化合物樟脑占该物种挥发油的53%（重量/重量）。讨论了甜叶假荆芥用于提取甜叶菊苷的潜在用途。
