Compadre C M, Pezzuto J M, Kinghorn A D, Kamath S K
Science. 1985 Jan 25;227(4685):417-9. doi: 10.1126/science.3880922.
Ancient Mexican botanical literature was systematically searched for new plant sources of intensely sweet substances. Lippia dulcis Trev., a sweet plant, emerged as a candidate for fractionation studies, and hernandulcin, a sesquiterpene, was isolated and judged by a human taste panel as more than 1000 times sweeter than sucrose. The structure of the sesquiterpene was determined spectroscopically and confirmed by chemical synthesis. Hernandulcin was nontoxic when administered orally to mice, and it did not induce bacterial mutation.
对古代墨西哥植物学文献进行了系统检索，以寻找新的高甜度植物来源。甜叶假荆芥（Lippia dulcis Trev.），一种甜味植物，成为了分级研究的候选对象，并且一种倍半萜类化合物——甜叶菊苷被分离出来，经人类味觉小组判定其甜度比蔗糖高1000多倍。通过光谱学确定了该倍半萜的结构，并通过化学合成得以证实。给小鼠口服甜叶菊苷无毒，且它不会诱导细菌突变。
