Wicomb W N, Cooper D K, Lanza R P, Novitzky D, Isaacs S
J Thorac Cardiovasc Surg. 1986 Jun;91(6):896-909.
The effects on the myocardium of the agonal period and subsequent management have been studied in the pig. Acute ischemia of the brain led to major temporary hemodynamic changes. Brain death, with or without hemodynamic support of the circulation, led to a significant reduction in subsequent myocardial function, associated with some depletion of the myocardial high-energy phosphate and glycogen reserves, although the rate of this depletion was reduced by anaerobic glycolysis. Although 24 hours' storage by continuous hypothermic perfusion of hearts taken from control animals led to only a minimal reduction in myocardial function, storage increased the reduction in function associated with brain death when intravenous fluid and dobutamine support had been given to maintain the brain dead pig in a normotensive state. Storage, however, reduced the anaerobic metabolism seen in hearts functioning in hypotensive brain dead pigs and led to replenishment of the glycogen stores.
在猪身上研究了濒死期及后续处理对心肌的影响。急性脑缺血导致主要的暂时性血流动力学改变。脑死亡，无论有无循环的血流动力学支持，都会导致随后心肌功能显著降低，同时伴有心肌高能磷酸盐和糖原储备的一些消耗，尽管无氧糖酵解降低了这种消耗的速率。虽然对取自对照动物的心脏进行连续低温灌注保存24小时仅导致心肌功能轻微降低，但当给予静脉输液和多巴酚丁胺支持以使脑死亡猪维持正常血压状态时，保存会增加与脑死亡相关的功能降低。然而，保存减少了低血压脑死亡猪心脏中的无氧代谢，并导致糖原储备的补充。
