Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China.
J Agric Food Chem. 2022 Mar 9;70(9):2957-2967. doi: 10.1021/acs.jafc.1c08301. Epub 2022 Feb 24.
is a potential probiotic fungus that is used to enhance Fuzhuan tea quality through fermentation and could reduce obesity by modulating gut dysbiosis. This study aimed to investigate the effects and possible mechanisms of killed (KEC) and its polysaccharides (ECP) in ulcerative colitis (UC) relief. KEC and ECP were administered to mice with dextran sulfate sodium-induced UC. The results showed that UC severity, intestinal inflammation, and tight junction protein levels were greatly improved. Furthermore, 16S rRNA sequencing results showed that , , , , , and were depleted, while and were enriched. A fecal microbial transplantation trial confirmed that KEC and ECP ameliorated UC by regulating gut dysbiosis. Thus, this research suggests that KEC and ECP are novel, potent, food-based anti-inflammatory agents that relieve UC by modulating gut dysbiosis.
是一种有潜力的益生菌真菌，用于通过发酵来提高茯砖茶的质量，并通过调节肠道菌群失调来减轻肥胖。本研究旨在探讨杀（KEC）及其多糖（ECP）对溃疡性结肠炎（UC）的缓解作用及可能的机制。KEC 和 ECP 被给予葡聚糖硫酸钠诱导的 UC 小鼠。结果表明，UC 严重程度、肠道炎症和紧密连接蛋白水平得到了很大改善。此外，16S rRNA 测序结果表明， 、 、 、 、 和 减少，而 和 增加。粪便微生物移植试验证实，KEC 和 ECP 通过调节肠道菌群失调来改善 UC。因此，本研究表明，KEC 和 ECP 是新型、有效、基于食品的抗炎剂，通过调节肠道菌群失调来缓解 UC。
