Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, 130062, People's Republic of China.
Food Funct. 2021 Dec 13;12(24):12812-12825. doi: 10.1039/d1fo02886c.
Obesity is a disease in humans and companion animals that can cause many chronic diseases. () is a dominant fungus in Fuzhuan tea. In this study, we aimed to investigate the possibility that may reduce diet-induced obesity by regulating the gut microbiota and measuring the differences in the gut microbiota of obese mice and dogs under supplementation. High-fat diet-fed C57BL/6J mice and beagle dogs were supplemented with live for 8 or 12 weeks. Faecal microbiota transplantation (FMT) and 16S rRNA sequencing were used to evaluate the relationship between the anti-obesity effect of and the gut microbiota. The results suggested that live reduced obesity and metabolic disorders in obese mice and dogs. 16S rRNA sequencing results revealed that decreased the Firmicutes/Bacteroidetes (F/B) ratio and the abundance of members of the Firmicutes phylum, including , , and , in obese mice, but the opposite was true in obese dogs. Furthermore, to investigate whether the antiobesity effect of can be attributed to gut microbiota, FMT and 16S rRNA sequencing were employed. The FMT trial confirmed that the anti-obesity effect of was mediated by modulating gut dysbiosis. In addition, we isolated live from faeces and found the β-hydroxy acid metabolite of monacolin K (MKA) in culture. Our research implies that has the potential to treat obesity as a novel probiotic.
肥胖是人类和伴侣动物的一种疾病，可导致许多慢性疾病。（）是茯砖茶中的优势真菌。在这项研究中，我们旨在研究（）是否可以通过调节肠道微生物群来减少饮食诱导的肥胖，并测量补充（）后肥胖小鼠和狗的肠道微生物群的差异。用高脂肪饮食喂养 C57BL/6J 小鼠和比格犬 8 或 12 周。采用粪便微生物群移植（FMT）和 16S rRNA 测序来评估（）对肥胖的抑制作用与肠道微生物群之间的关系。结果表明，（）可减轻肥胖小鼠和狗的肥胖和代谢紊乱。16S rRNA 测序结果显示，（）降低了肥胖小鼠的厚壁菌门/拟杆菌门（F/B）比值和厚壁菌门成员的丰度，包括，，和，而肥胖狗则相反。此外，为了研究（）的减肥效果是否归因于肠道微生物群，我们进行了 FMT 和 16S rRNA 测序。FMT 试验证实，（）的减肥效果是通过调节肠道菌群失调介导的。此外，我们从粪便中分离出（），并在（）培养物中发现了莫纳可林 K（MKA）的β-羟基酸代谢物。我们的研究表明，（）作为一种新型益生菌具有治疗肥胖的潜力。
