Giuffrè Chiara, Syed Sara, Pockar Sasa, Ashworth Jane L, Steeples Laura R
Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Faculty of Biology, Medicine & Health, University of Manchester, Manchester, UK.
Ocul Immunol Inflamm. 2023 Apr;31(3):589-593. doi: 10.1080/09273948.2022.2032194. Epub 2022 Feb 24.
To describe a case of interferon-beta retinopathy associated with paracentral acute middle maculopathy.
A 15-year-old girl with Epstein-Barr virus-positive advanced nasopharyngeal carcinoma WAS REFERRED with reduced visual acuity. Multimodal imaging findings, including optical coherence tomography angiography, at presentation and evolution following cessation of interferon therapy are presented.
The presentation of paracentral acute middle maculopathy in this patient supports the presumed ischaemic pathogenesis in interferon retinopathy. The imaging findings provide evidence of deep capillary plexus involvement in interferon retinopathy with evolution to permanent structural damage within the inner nuclear layer.
描述一例与中心旁急性黄斑中病变相关的β-干扰素视网膜病变病例。
一名15岁的女孩，患有爱泼斯坦-巴尔病毒阳性的晚期鼻咽癌，因视力下降前来就诊。本文展示了在停止干扰素治疗后该患者就诊时及病情发展过程中的多模态成像结果，包括光学相干断层扫描血管造影。
该患者出现的中心旁急性黄斑中病变支持了干扰素视网膜病变中推测的缺血性发病机制。成像结果为干扰素视网膜病变中深层毛细血管丛受累并发展为内核层永久性结构损伤提供了证据。
