Department of Obstetrics and Gynaecology, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur 56000, Malaysia.
Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur 56000, Malaysia.
Cells. 2022 Feb 10;11(4):614. doi: 10.3390/cells11040614.
The pathophysiology of pre-eclampsia involves two major pathways, namely systemic oxidative stress and subsequent generalised inflammatory response, which eventually culminates in endothelial cell injury and the syndrome of pre-eclampsia with multi-organ dysfunction. Aspirin has been used to reduce the risk of pre-eclampsia, but it only possesses anti-inflammatory properties without any antioxidant effect. Hence, it can only partially alleviate the problem. Tocotrienols are a unique form of vitamin E with strong antioxidant and anti-inflammatory properties that can be exploited as a preventive agent for pre-eclampsia. Many preclinical models showed that tocotrienol can also prevent hypertension and ischaemic/reperfusion injury, which are the two main features in pre-eclampsia. This review explores the mechanism of action of tocotrienol in relation to the pathophysiology of pre-eclampsia. In conclusion, the study provides sufficient justification for the establishment of a large clinical trial to thoroughly assess the capability of tocotrienol in preventing pre-eclampsia.
子痫前期的病理生理学涉及两个主要途径，即全身氧化应激和随后的全身性炎症反应，最终导致内皮细胞损伤和多器官功能障碍的子痫前期综合征。阿司匹林已被用于降低子痫前期的风险，但它仅具有抗炎特性而没有抗氧化作用。因此，它只能部分缓解问题。生育三烯酚是维生素 E 的一种独特形式，具有很强的抗氧化和抗炎特性，可作为子痫前期的预防剂。许多临床前模型表明，生育三烯酚还可以预防高血压和缺血/再灌注损伤，这是子痫前期的两个主要特征。本综述探讨了生育三烯酚与子痫前期病理生理学相关的作用机制。总之，该研究为进行大规模临床试验以彻底评估生育三烯酚预防子痫前期的能力提供了充分的依据。
