Tumor Microenvironment and Resistance to Treatment Laboratory, Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Institut régional du Cancer de Montpellier, 34298 Montpellier, France.
Cells. 2022 Feb 15;11(4):681. doi: 10.3390/cells11040681.
The BCL-2-associated athanogene (BAG) family is a multifunctional group of co-chaperones that are evolutionarily conserved from yeast to mammals. In addition to their common BAG domain, these proteins contain, in their sequences, many specific domains/motifs required for their various functions in cellular quality control, such as autophagy, apoptosis, and proteasomal degradation of misfolded proteins. The BAG family includes six members (BAG1 to BAG6). Recent studies reported their roles in autophagy and/or mitophagy through interaction with the autophagic machinery (LC3, Beclin 1, P62) or with the PINK1/Parkin signaling pathway. This review describes the mechanisms underlying BAG family member functions in autophagy and mitophagy and the consequences in physiopathology.
BCL-2 相关抗凋亡基因（BAG）家族是一类多功能伴侣蛋白，从酵母到哺乳动物在进化上都具有保守性。除了共同的 BAG 结构域外，这些蛋白在序列上还包含许多特定的结构域/基序，这些结构域/基序对于它们在细胞质量控制中的各种功能（如自噬、细胞凋亡和错误折叠蛋白的蛋白酶体降解）是必需的。BAG 家族包括六个成员（BAG1 到 BAG6）。最近的研究报告称，它们通过与自噬机制（LC3、Beclin 1、P62）或 PINK1/Parkin 信号通路相互作用，在自噬和/或线粒体自噬中发挥作用。本综述描述了 BAG 家族成员在自噬和线粒体自噬中的功能机制及其在生理病理学中的后果。
