da Costa Paulo J, Hamdane Malika, Buée Luc, Martin Franck
Institut de Biologie Moléculaire et Cellulaire, "Architecture et Réactivité de l'ARN" CNRS UPR9002, Université de Strasbourg, 2, Allée Konrad Roentgen, F-67084 Strasbourg, France.
Inserm, CHU Lille, UMR-S 1172, "Alzheimer Tauopathies", Labex DISTALZ, University Lille, Bâtiment Biserte, 1, Place de Verdun, F-59045 Lille, France.
Biomedicines. 2022 Jan 23;10(2):241. doi: 10.3390/biomedicines10020241.
Tau proteins are known to be mainly involved in regulation of microtubule dynamics. Besides this function, which is critical for axonal transport and signal transduction, tau proteins also have other roles in neurons. Moreover, tau proteins are turned into aggregates and consequently trigger many neurodegenerative diseases termed tauopathies, of which Alzheimer's disease (AD) is the figurehead. Such pathological aggregation processes are critical for the onset of these diseases. Among the various causes of tau protein pathogenicity, abnormal tau mRNA metabolism, expression and dysregulation of tau post-translational modifications are critical steps. Moreover, the relevance of tau function to general mRNA metabolism has been highlighted recently in tauopathies. In this review, we mainly focus on how mRNA metabolism impacts the onset and development of tauopathies. Thus, we intend to portray how mRNA metabolism of, or mediated by, tau is associated with neurodegenerative diseases.
已知tau蛋白主要参与微管动力学的调节。除了对轴突运输和信号转导至关重要的这一功能外，tau蛋白在神经元中还具有其他作用。此外，tau蛋白会形成聚集体，从而引发许多被称为tau蛋白病的神经退行性疾病，其中阿尔茨海默病（AD）是最为典型的。这种病理性聚集过程对这些疾病的发病至关重要。在tau蛋白致病性的各种原因中，异常的tau mRNA代谢、tau蛋白翻译后修饰的表达和失调是关键步骤。此外，tau蛋白功能与一般mRNA代谢的相关性最近在tau蛋白病中得到了强调。在这篇综述中，我们主要关注mRNA代谢如何影响tau蛋白病的发病和发展。因此，我们旨在描绘由tau介导的或tau自身的mRNA代谢如何与神经退行性疾病相关联。
