用于检测早期结直肠癌的生物标志物。
Biomarkers to Detect Early-Stage Colorectal Cancer.
作者信息
Keenan Jacqueline I, Frizelle Frank A
机构信息
Department of Surgery, University of Otago Christchurch, Christchurch 8140, New Zealand.
出版信息
Biomedicines. 2022 Jan 25;10(2):255. doi: 10.3390/biomedicines10020255.
Abstract
Colorectal cancer is a leading cause of mortality worldwide. The high incidence and the acceleration of incidence in younger people reinforces the need for better techniques of early detection. The use of noninvasive biomarkers has potential to more accurately inform how patients are prioritised for clinical investigation, which, in turn, may ultimately translate into improved survival for those subsequently found to have curable-stage CRC. This review surveys a wide range of CRC biomarkers that may (alone or in combination) identify symptomatic patients presenting in primary care who should be progressed for clinical investigation.
摘要
结直肠癌是全球主要的死亡原因之一。其高发病率以及在年轻人中发病率的加速上升，凸显了对更好的早期检测技术的需求。使用非侵入性生物标志物有可能更准确地告知如何对患者进行临床检查的优先级排序，这反过来可能最终转化为提高那些随后被发现处于可治愈阶段的结直肠癌患者的生存率。本综述调查了广泛的结直肠癌生物标志物，这些生物标志物可能（单独或联合使用）识别出在初级保健中出现症状、应推进至临床检查的患者。
相似文献
1
Biomarkers to Detect Early-Stage Colorectal Cancer.
Biomedicines. 2022 Jan 25;10(2):255. doi: 10.3390/biomedicines10020255.
2
Biomarkers in Colorectal Cancer Screening.
J Natl Compr Canc Netw. 2016 Aug;14(8):1033-40. doi: 10.6004/jnccn.2016.0109.
3
Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer.
Dis Markers. 2019 Mar 3;2019:2673543. doi: 10.1155/2019/2673543. eCollection 2019.
4
Fecal occult blood test for colorectal cancer screening: an evidence-based analysis.
Ont Health Technol Assess Ser. 2009;9(10):1-40. Epub 2009 Sep 1.
5
Cost-effectiveness of High-performance Biomarker Tests vs Fecal Immunochemical Test for Noninvasive Colorectal Cancer Screening.
Clin Gastroenterol Hepatol. 2018 Apr;16(4):504-512.e11. doi: 10.1016/j.cgh.2017.07.011. Epub 2017 Jul 18.
6
Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer.
Int J Mol Sci. 2019 Dec 2;20(23):6082. doi: 10.3390/ijms20236082.
7
Detection of aberrant methylated SEPT9 and NTRK3 genes in sporadic colorectal cancer patients as a potential diagnostic biomarker.
Oncol Lett. 2016 Dec;12(6):5335-5343. doi: 10.3892/ol.2016.5327. Epub 2016 Oct 31.
8
Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer.
J Transl Med. 2019 Aug 6;17(1):253. doi: 10.1186/s12967-019-2008-y.
9
Detection of serological biomarkers by proximity extension assay for detection of colorectal neoplasias in symptomatic individuals.
J Transl Med. 2013 Oct 10;11:253. doi: 10.1186/1479-5876-11-253.
10
Tests and investigations for colorectal cancer screening.
Clin Biochem. 2014 Jul;47(10-11):921-39. doi: 10.1016/j.clinbiochem.2014.04.019. Epub 2014 Apr 24.
引用本文的文献
1
miR-182-5p facilitates colorectal cancer progression through manipulating neurocalcin delta mediated Wnt/β-catenin signalling.
Eur J Med Res. 2025 May 2;30(1):352. doi: 10.1186/s40001-025-02625-0.
2
Exploration of mRNA-modifying METTL3 oncogene as momentous prognostic biomarker responsible for colorectal cancer development.
Open Med (Wars). 2025 Mar 26;20(1):20251167. doi: 10.1515/med-2025-1167. eCollection 2025.
3
Wnt signaling in cancer: from biomarkers to targeted therapies and clinical translation.
Mol Cancer. 2025 Apr 2;24(1):107. doi: 10.1186/s12943-025-02306-w.
4
Early Onset Colorectal Cancer: Molecular Underpinnings Accelerating Occurrence.
Cell Mol Gastroenterol Hepatol. 2025;19(2):101425. doi: 10.1016/j.jcmgh.2024.101425. Epub 2024 Nov 5.
5
Targeted Therapy for Cancers: From Ongoing Clinical Trials to FDA-Approved Drugs.
Int J Mol Sci. 2023 Sep 3;24(17):13618. doi: 10.3390/ijms241713618.
6
The Importance of Evaluating Serum Levels of Tumor Markers M2-PK and Inhibin A in Patients Undergoing Colonoscopy.
Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231194492. doi: 10.1177/15330338231194492.
7
Detection of Chitinase 3-Like 1 in Symptomatic Primary Care Patient Faecal Samples is Not a Reliable Biomarker of Colonic Lesions.
Asian Pac J Cancer Prev. 2023 Jul 1;24(7):2289-2293. doi: 10.31557/APJCP.2023.24.7.2289.
8
A Hybrid Algorithm of ML and XAI to Prevent Breast Cancer: A Strategy to Support Decision Making.
Cancers (Basel). 2023 Apr 25;15(9):2443. doi: 10.3390/cancers15092443.
9
EMR1/ADGRE1 Expression in Cancer Cells Upregulated by Tumor-Associated Macrophages Is Related to Poor Prognosis in Colorectal Cancer.
Biomedicines. 2022 Dec 2;10(12):3121. doi: 10.3390/biomedicines10123121.
10
Detection of Fusobacterium nucleatum DNA in primary care patient stool samples does not predict progression of colorectal neoplasia.
PLoS One. 2022 Jun 3;17(6):e0269541. doi: 10.1371/journal.pone.0269541. eCollection 2022.
本文引用的文献
1
The diagnostic accuracy of the faecal immunohistochemical test in identifying significant bowel disease in a symptomatic population.
Colorectal Dis. 2022 Mar;24(3):257-263. doi: 10.1111/codi.15994. Epub 2021 Nov 30.
2
drives a pro-inflammatory intestinal microenvironment through metabolite receptor-dependent modulation of IL-17 expression.
Gut Microbes. 2021 Jan-Dec;13(1):1987780. doi: 10.1080/19490976.2021.1987780.
3
Faecal Diagnostic Biomarkers for Colorectal Cancer.
Cancers (Basel). 2021 Nov 7;13(21):5568. doi: 10.3390/cancers13215568.
4
Tumor-Associated Macrophages (TAMs) in Colorectal Cancer (CRC): From Mechanism to Therapy and Prognosis.
Int J Mol Sci. 2021 Aug 6;22(16):8470. doi: 10.3390/ijms22168470.
5
Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.
JAMA Surg. 2021 Sep 1;156(9):865-874. doi: 10.1001/jamasurg.2021.2380.
6
Diagnostic accuracy of fecal calprotectin in predicting significant gastrointestinal diseases.
JGH Open. 2021 May 6;5(6):647-652. doi: 10.1002/jgh3.12548. eCollection 2021 Jun.
7
Comparative effectiveness of five fecal immunochemical tests using colonoscopy as the gold standard: study protocol.
Contemp Clin Trials. 2021 Jul;106:106430. doi: 10.1016/j.cct.2021.106430. Epub 2021 May 8.
8
Key biomarkers within the colorectal cancer related inflammatory microenvironment.
Sci Rep. 2021 Apr 12;11(1):7940. doi: 10.1038/s41598-021-86941-5.
9
Multitarget Stool mRNA Test for Detecting Colorectal Cancer Lesions Including Advanced Adenomas.
Cancers (Basel). 2021 Mar 11;13(6):1228. doi: 10.3390/cancers13061228.
10
Racial Disparities in Epigenetic Aging of the Right vs Left Colon.
J Natl Cancer Inst. 2021 Nov 29;113(12):1779-1782. doi: 10.1093/jnci/djaa206.
Zotero 插件