Banegas Inmaculada, Prieto Isabel, Segarra Ana Belén, Vives Francisco, Martínez-Cañamero Magdalena, Durán Raquel, Luna Juan de Dios, de Gasparo Marc, Domínguez-Vías Germán, Ramírez-Sánchez Manuel
Department of Health Sciences, University of Jaén, 23071 Jaen, Spain.
Department of Physiology, Faculty of Health Sciences, University of Granada, 18071 Granada, Spain.
Biomedicines. 2022 Jan 29;10(2):326. doi: 10.3390/biomedicines10020326.
In emotional processing, dopamine (DA) plays an essential role, and its deterioration involves important consequences. Under physiological conditions, dopamine exhibits brain asymmetry and coexists with various neuropeptides that can coordinate the processing of brain functions. Brain asymmetry can extend into a broader concept of asymmetric neurovisceral integration, including behavior. The study of the activity of neuropeptide regulatory enzymes (neuropeptidases, NPs) is illustrative. We have observed that the left and right brain areas interact intra- and inter-hemispherically, as well as with peripheral tissues or with physiological parameters such as blood pressure or with behaviors such as turning preference. To obtain data that reflect this integrative behavior, we simultaneously analyzed the impact of left or right brain DA depletion on the activity of various NPs in corticolimbic regions of the left and right hemispheres, such as the medial prefrontal cortex, amygdala and hippocampus, as well as on the plasma activity of the same aminopeptidase activities (APs) and on systolic blood pressure (SBP). Intra- and inter-hemispheric interactions as well as the interactions of NPs from the left or right hemispheres were analyzed with the same plasma APs and the SBP obtained from sham and from left or right lesioned rats. The results demonstrate a complex profile depending on the hemisphere considered. They definitively confirm an asymmetric neurovisceral integration and reveal a higher level of inter-hemispheric corticolimbic interactions including with SBP after left dopamine depletion.
在情绪加工过程中，多巴胺（DA）起着至关重要的作用，其功能退化会产生重要后果。在生理条件下，多巴胺呈现脑区不对称性，并与多种神经肽共存，这些神经肽可协调脑功能的加工。脑区不对称性可扩展为一个更广泛的概念，即不对称神经内脏整合，包括行为。对神经肽调节酶（神经肽酶，NPs）活性的研究具有启发性。我们观察到，左右脑区在半球内和半球间相互作用，还与外周组织、血压等生理参数或转向偏好等行为相互作用。为了获得反映这种整合行为的数据，我们同时分析了左右脑多巴胺耗竭对左右半球皮质边缘区域（如内侧前额叶皮质、杏仁核和海马体）中各种神经肽酶活性的影响，以及对相同氨肽酶活性（APs）的血浆活性和收缩压（SBP）的影响。利用从假手术组以及左、右损伤大鼠获得的相同血浆氨肽酶活性和收缩压，分析了半球内和半球间的相互作用以及左右半球神经肽酶的相互作用。结果表明，根据所考虑的半球不同，呈现出复杂的情况。这些结果明确证实了不对称神经内脏整合，并揭示了左多巴胺耗竭后包括与收缩压在内的半球间皮质边缘相互作用水平更高。
