Menegon Francesca, Capello Katia, Tarakdjian Jacopo, Pasqualin Dario, Cunial Giovanni, Andreatta Sara, Dellamaria Debora, Manca Grazia, Farina Giovanni, Di Martino Guido
Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020 Legnaro, Italy.
Antibiotics (Basel). 2022 Feb 10;11(2):231. doi: 10.3390/antibiotics11020231.
The quantification of antimicrobial usage (AMU) in food-producing animals can help identify AMU risk factors, thereby enhancing appropriate stewardship policies and strategies for a more rational use. AMU in a sample of 34 farms in the Province of Trento (north-eastern Italy) from 2018 to 2020 was expressed as defined daily doses for animals per population correction unit according to European Surveillance of Veterinary Antimicrobial Consumption guidelines (DDDvet) and according to Italian guidelines (DDDAit). A retrospective analysis was carried out to test the effects of several husbandry practices on AMU. Overall, the average AMU ranged between 6.5 DDDAit in 2018 and 5.2 DDDAit in 2020 (corresponding to 9 and 7 DDDvet, respectively), showing a significant trend of decrement (-21.3%). Usage of the highest priority critically important antimicrobials (HPCIA) was reduced by 83% from 2018 to 2020. Quarantine management, available space, water supply, animals' cleanliness and somatic cell count had no significant association with AMU. Rather, farms with straw-bedded cubicles had lower AMU levels than those with mattresses and concrete floors ( < 0.05). In conclusion, this study evidenced a decrement in AMU, particularly regarding HPCIA, but only a few risk factors due to farm management.
对食用动物抗菌药物使用量（AMU）进行量化有助于识别AMU风险因素，从而加强适当的管理政策和策略，以实现更合理的使用。根据欧洲兽医抗菌药物消费监测指南（DDDvet）和意大利指南（DDDAit），2018年至2020年期间，对意大利东北部特伦托省34个农场的样本中的AMU，按照每种群校正单位动物的规定日剂量来表示。进行了一项回顾性分析，以测试几种饲养方式对AMU的影响。总体而言，平均AMU在2018年的6.5 DDDAit至2020年的5.2 DDDAit之间（分别对应9和7 DDDvet），呈现出显著的下降趋势（-21.3%）。从2018年到2020年，最高优先级的 critically important antimicrobials（HPCIA）的使用量减少了83%。检疫管理、可用空间、供水、动物清洁度和体细胞计数与AMU没有显著关联。相反，使用稻草铺垫畜栏的农场的AMU水平低于使用床垫和混凝土地面的农场（<0.05）。总之，本研究证明了AMU的下降，特别是关于HPCIA，但农场管理导致的风险因素较少。
