Xu Joyce, Su Xiaoyang, Burley Stephen K, Zheng X F Steven
Rutgers Cancer Institute of New Jersey, Rutgers, The State University of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA.
Department of Medicine, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, 125 Paterson Street, New Brunswick, NJ 08901, USA.
Antioxidants (Basel). 2022 Feb 21;11(2):427. doi: 10.3390/antiox11020427.
SOD1 is the major superoxide dismutase responsible for catalyzing dismutation of superoxide to hydrogen peroxide and molecular oxygen. It is well known as an essential antioxidant enzyme for maintaining cellular redox homeostasis. SOD1 dysregulation has been associated with many diseases, including amyotrophic lateral sclerosis (ALS), cancer, accelerated aging, and age-related diseases. Recent studies also revealed that SOD1 can serve as a regulatory protein in cell signaling, transcription, and ribosome biogenesis. Notably, SOD1 is localized in the nucleus under both normal and pathological conditions, contributing to oxidative stress response and growth control. Moreover, increasing evidence points to the importance of nuclear SOD1 in the pathogenesis of ALS and cancer.
超氧化物歧化酶1（SOD1）是主要的超氧化物歧化酶，负责催化超氧化物歧化为过氧化氢和分子氧。它作为维持细胞氧化还原稳态的一种必需抗氧化酶而广为人知。SOD1失调与许多疾病相关，包括肌萎缩侧索硬化症（ALS）、癌症、加速衰老以及与年龄相关的疾病。最近的研究还表明，SOD1可作为细胞信号传导、转录和核糖体生物发生中的一种调节蛋白。值得注意的是，在正常和病理条件下，SOD1都定位于细胞核中，有助于氧化应激反应和生长控制。此外，越来越多的证据表明细胞核SOD1在ALS和癌症的发病机制中具有重要作用。
