使用锝标记变性红细胞闪烁扫描术检测脾脏组织——单中心定量分析

Detection of Splenic Tissue Using Tc-Labelled Denatured Red Blood Cells Scintigraphy-A Quantitative Single Center Analysis.

作者信息

Holzgreve Adrien, Völter Friederike, Delker Astrid, Kunz Wolfgang G, Fabritius Matthias P, Brendel Matthias, Albert Nathalie L, Bartenstein Peter, Unterrainer Marcus, Unterrainer Lena M

机构信息

Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.

Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany.

出版信息

Diagnostics (Basel). 2022 Feb 14;12(2):486. doi: 10.3390/diagnostics12020486.

DOI:10.3390/diagnostics12020486

PMID:35204576

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8871479/

Abstract

BACKGROUND

Red blood cells (RBC) scintigraphy can be used not only for detection of bleeding sites, but also of spleen tissue. However, there is no established quantitative readout. Therefore, we investigated uptake in suspected splenic lesions in direct quantitative correlation to sites of physiologic uptake in order to objectify the readout.

METHODS

20 patients with Tc-99m-labelled RBC scintigraphy and SPECT/low-dose CT for assessment of suspected splenic tissue were included. Lesions were rated as vital splenic or non-splenic tissue, and uptake and physiologic uptake of bone marrow, pancreas, and spleen were then quantified using a volume-of-interest based approach. Hepatic uptake served as a reference.

RESULTS

The median uptake ratio was significantly higher in splenic (2.82 (range, 0.58-24.10), = 47) compared to other lesions (0.49 (0.01-0.83), = 7), < 0.001, and 5 lesions were newly discovered. The median pancreatic uptake was 0.09 (range 0.03-0.67), bone marrow 0.17 (0.03-0.45), and orthotopic spleen 14.45 (3.04-29.82). Compared to orthotopic spleens, the pancreas showed lowest uptake (0.09 vs. 14.45, = 0.004). Based on pancreatic uptake we defined a cutoff (0.75) to distinguish splenic from other tissues.

CONCLUSION

As the uptake in extra-splenic regions is invariably low compared to splenules, it can be used as comparator for evaluating suspected splenic tissues.

摘要

背景

红细胞（RBC）闪烁扫描不仅可用于检测出血部位，还可用于检测脾脏组织。然而，目前尚无既定的定量读数方法。因此，我们研究了疑似脾脏病变的摄取情况，并将其与生理摄取部位进行直接定量关联，以便使读数客观化。

方法

纳入20例进行了锝-99m标记红细胞闪烁扫描及SPECT/低剂量CT以评估疑似脾脏组织的患者。将病变评定为有活性的脾脏组织或非脾脏组织，然后使用基于感兴趣区的方法对骨髓、胰腺和脾脏的摄取及生理摄取进行定量。肝脏摄取作为对照。

结果

与其他病变（0.49（0.01 - 0.83），n = 7）相比，脾脏病变的摄取率中位数显著更高（2.82（范围0.58 - 24.10），n = 47），P < 0.001，且新发现了5个病变。胰腺摄取率中位数为0.09（范围0.03 - 0.67），骨髓为0.17（0.03 - 0.45），原位脾脏为14.45（3.04 - 29.82）。与原位脾脏相比，胰腺的摄取最低（0.09对14.45，P = 0.004）。基于胰腺摄取情况，我们定义了一个临界值（0.75）以区分脾脏组织与其他组织。