Department of Cardiology, University Hospital of Burgos, 09006 Burgos, Spain.
Department Clinical Analysis, University Hospital of Burgos, 09006 Burgos, Spain.
Biomolecules. 2022 Feb 2;12(2):245. doi: 10.3390/biom12020245.
Frailty has traditionally been studied in the elderly population but scarcely in younger individuals. The objective of the present study is to analyze differences according to age in the diagnostic performance of cardiac biomarkers to predict frailty in patients admitted to the hospital for acute heart failure (AHF). A frailty assessment was performed with the SPPB and FRAIL scales (score > 3). We included 201 patients who were divided according to age: those older and younger than 75 years. In the younger group, no biomarker was related to the presence of frailty. This was mainly determined by age and comorbidities. In the elderly group, NT-proBNP was significantly related to the presence of frailty, but none of the baseline characteristics were. The best cut-off point in the elderly group for NT-proBNP was 4000 pg/mL. The area under the curve (AUC) for proBNP for frailty detection was 0.62 in the elderly. Another similar frailty scale, the SPPB, also showed a similar AUC in this group; however, adding the NT-proBNP (one point if NT-proBNP < 4000 pg/mL), it showed a slightly higher yield (AUC 0.65). The addition of biomarkers could improve frailty detection in members of the elderly population who are admitted to the hospital for AHF.
衰弱传统上是在老年人群中进行研究，但在年轻人群中几乎没有研究。本研究的目的是分析年龄差异对心脏生物标志物诊断性能的影响，以预测因急性心力衰竭（AHF）住院的患者的衰弱情况。使用 SPPB 和 FRAIL 量表（评分>3）进行衰弱评估。我们纳入了 201 名患者，根据年龄分为年龄较大和年龄较小两组（>75 岁）。在年轻组中，没有生物标志物与衰弱有关。这主要取决于年龄和合并症。在老年组中，NT-proBNP 与衰弱的存在显著相关，但没有任何基线特征与衰弱相关。老年组中 NT-proBNP 的最佳截断值为 4000 pg/mL。对于老年组，proBNP 检测衰弱的曲线下面积（AUC）为 0.62。另一个类似的衰弱量表 SPPB 在该组中也显示出相似的 AUC；然而，加入 NT-proBNP（如果 NT-proBNP<4000 pg/mL 则加 1 分），其收益略高（AUC 为 0.65）。在因 AHF 住院的老年人群中，添加生物标志物可能会提高对衰弱的检测能力。
