Vasto Sonya, Amato Alessandra, Proia Patrizia, Baldassano Sara
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Viale delle Scienze, 90128 Palermo, Italy.
Sport and Exercise Sciences Research Unit, Department of Psychological, Pedagogical and Educational Sciences, University of Palermo, 90128 Palermo, Italy.
Biology (Basel). 2022 Feb 11;11(2):296. doi: 10.3390/biology11020296.
We showed that twenty weeks of SuperJump activity, an innovative workout training performed on an elastic minitrampoline, reduced bone resorption and increased bone formation in eumenorrheic women acting on the key points of the regulation of bone metabolism. The present study analyzed whether the gastrointestinal hormones are involved in the mechanism of action and if it has an impact on glucose homeostasis. The control group was composed of twelve women, similar to the exercise group that performed SuperJump activity for twenty weeks. The analysis was performed on blood samples and investigated GLP-1, GIP, GLP-2, PYY, ghrelin, glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity. The results showed that the activity contributes to raising the GLP-1and GIP levels, and not on GLP-2, PYY, and ghrelin, which did not change. Moreover, SuperJump activity significantly reduced fasting insulin, glucose, insulin resistance, and increased insulin sensitivity but did not affect beta cell function. These data suggest that GLP-1, and GIP are involved in the mechanism of action that improves bone and glucose homeostasis following 20 weeks of SuperJump activity in eumenorrheic women.
我们发现，在弹性小型蹦床上进行的创新型健身训练——SuperJump活动持续20周，可减少月经正常女性的骨吸收并增加骨形成，这一过程作用于骨代谢调节的关键点。本研究分析了胃肠激素是否参与其作用机制，以及该活动是否对葡萄糖稳态有影响。对照组由12名女性组成，与进行了20周SuperJump活动的运动组女性情况相似。分析针对血液样本展开，检测了胰高血糖素样肽-1（GLP-1）、葡萄糖依赖性促胰岛素多肽（GIP）、胰高血糖素样肽-2（GLP-2）、肽YY（PYY）、胃饥饿素、葡萄糖、胰岛素、胰岛素抵抗、β细胞功能和胰岛素敏感性。结果显示，该活动有助于提高GLP-1和GIP水平，但对GLP-2、PYY和胃饥饿素无影响，这三者未发生变化。此外，SuperJump活动显著降低了空腹胰岛素、葡萄糖水平及胰岛素抵抗，并提高了胰岛素敏感性，但未影响β细胞功能。这些数据表明，GLP-1和GIP参与了月经正常女性在进行20周SuperJump活动后改善骨骼和葡萄糖稳态的作用机制。
