Baldassano Sara, Accardi Giulia, Vasto Sonya
Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), University of Palermo, 90128, Italy.
Dipartimento di Biopatologia e Biotecnologie Mediche (Di.Bi.Med), University of Palermo, Italy.
Eur J Med Chem. 2017 Dec 15;142:486-492. doi: 10.1016/j.ejmech.2017.09.013. Epub 2017 Sep 15.
Dietary β-glucans are soluble fibers with potentially health-promoting effects. Gut peptides are important signals in the regulation of energy and glucose homeostasis. This article reviews the effects of different enriched β-glucan food consumption on immune responses, inflammation, gut hormone and cancer. Gut hormones are influenced by enriched β-glucan food consumption and levels of such peptide as YY, ghrelin, glucagon-like peptide 1 and 2 in humans influence serum glucose concentration as well as innate and adaptive immunity. Cancer cell development is also regulated by obesity and glucose dishomeostasy that are influenced by β-glucan food consumption that in turn regulated gut hormones.
膳食β-葡聚糖是具有潜在健康促进作用的可溶性纤维。肠道肽是调节能量和葡萄糖稳态的重要信号。本文综述了食用不同富含β-葡聚糖的食物对免疫反应、炎症、肠道激素和癌症的影响。肠道激素受富含β-葡聚糖食物摄入的影响，人体内诸如酪酪肽、胃饥饿素、胰高血糖素样肽1和2等此类肽的水平会影响血清葡萄糖浓度以及先天性和适应性免疫。癌细胞的发展也受肥胖和葡萄糖稳态失衡的调节，而肥胖和葡萄糖稳态失衡受β-葡聚糖食物摄入的影响，β-葡聚糖食物摄入又反过来调节肠道激素。
