子宫内膜癌患者中 （rs1050450）、 （rs225014）和 （rs7579）基因多态性的评估。
An Assessment of (rs1050450), (rs225014) and (rs7579) Gene Polymorphisms in Women with Endometrial Cancer.
机构信息
Department of Gynecology and Obstetrics, Fryderyk Chopin University Hospital No. 1, 35-055 Rzeszow, Poland.
Laboratory of Molecular Biology, Centre for Innovative Research in Medical and Natural Sciences, College of Medical Sciences, University of Rzeszow, 35-959 Rzeszow, Poland.
出版信息
Genes (Basel). 2022 Jan 21;13(2):188. doi: 10.3390/genes13020188.
BACKGROUND
Numerous studies indicate a relationship between the presence of (rs1050450), (rs225014) and (rs7579) gene polymorphisms and the development of chronic or neoplastic diseases. However, there are no reports on the influence of these polymorphisms on the development of endometrial cancer.
METHODS
543 women participated in the study. The study group consisted of 269 patients with diagnosed endometrial cancer. The control group consisted of 274 healthy women. Blood samples were drawn from all the participants. The PCR-RFLP method was used to determine polymorphisms in the (rs225014) and (rs1050450) genes. The analysis of polymorphisms in the (rs7579) gene was performed by means of TaqMan probes.
RESULTS
There was a 1.99-fold higher risk of developing endometrial cancer in CC homozygotes, (rs225014) polymorphism (95% Cl 1.14-3.53, = 0.017), compared to TT homozygotes. There was no correlation between the occurrence of (rs1050450) and (rs7579) polymorphisms and endometrial cancer.
CONCLUSION
Carriers of the (rs225014) polymorphism may be predisposed to the development of endometrial cancer. Further research confirming this relationship is recommended.
背景
许多研究表明，基因多态性(rs1050450)、(rs225014)和(rs7579)的存在与慢性或肿瘤性疾病的发展之间存在关系。然而，目前尚无关于这些多态性对子宫内膜癌发展影响的报道。
方法
543 名女性参与了这项研究。研究组包括 269 名确诊为子宫内膜癌的患者，对照组包括 274 名健康女性。所有参与者均抽取血液样本。采用 PCR-RFLP 方法检测(rs225014)和(rs1050450)基因的多态性。采用 TaqMan 探针分析(rs7579)基因的多态性。
结果
与 TT 纯合子相比，CC 纯合子患子宫内膜癌的风险增加了 1.99 倍(rs225014)多态性(95% Cl 1.14-3.53，=0.017)。(rs1050450)和(rs7579)多态性与子宫内膜癌的发生无相关性。
结论
携带(rs225014)多态性的个体可能易患子宫内膜癌。建议进一步研究证实这种相关性。
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