Association of Interleukin Genes and with Parameters of Overweight in Military Students.

BACKGROUND

To date, nearly 300 single-nucleotide polymorphisms (SNPs) associated with BMI, waist-to-hip ratio, and other adiposity traits have been identified by GWAS. With regards to , at least 49 -associated polymorphisms have been reported. However, little is known regarding the relationship between SNPs of the gene and the risk of obesity in young men. The aim of the present study was to investigate the relationship between SNPs of the and genes and the risk of obesity in young men.

METHODS

A cohort of 139 male students were enrolled and the following and SNPs were analyzed: (rs1518110), (rs3024491), (rs2834167). The subjects were divided into groups depending on obesity parameters: body mass index (BMI), fat mass index (FMI) and fat percentage (Fat%). Statistical analysis was conducted for a single locus and haplotypes, an association between SNPs and body composition parameters was tested with four genetic models: dominant, recessive, codominant and overdominant mode of inheritance (MOI).

RESULTS

Significant association was found for interaction (rs1518110) × (rs2834167) with Fat% value exceeding 20 in codominant (-value = 0.03, OR = 0.34, 95% CI 0.08 1.44) and dominant model (-value = 0.03, OR = 0.34, 95% CI 0.08 1.44) Conclusion: Our study shows for the first time that there is a correlation between the occurrence of specific polymorphisms of gene (rs1518110, rs3024491 and rs2834167) and the possibility of obesity.