Maculewicz Ewelina, Mastalerz Andrzej, Antkowiak Bożena, Antkowiak Oktawiusz, Garbacz Aleksandra, Szarska Ewa, Rusin Paweł, Cywińska Anna, Białek Agnieszka, Cięszczyk Paweł
Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, 00-968 Warsaw, Poland.
Military Institute of Hygiene and Epidemiology, 01-163 Warsaw, Poland.
Biol Sport. 2022 Oct;39(4):1117-1125. doi: 10.5114/biolsport.2023.118336. Epub 2022 Sep 5.
The main aim of this study was to investigate the association between 5 polymorphisms of the interleukin 10 () gene and body composition parameters in physically active young men. A cohort of 131 young men was enrolled and the following single-nucleotide polymorphisms (SNPs) were analysed: rs1518111, rs1878672, rs3024496, rs3024498 and rs3024505. The subjects were divided into groups depending on obesity parameters: body mass index (BMI) and percentage of body fat tissue (fat %). Statistical analysis was conducted for alleles, genotypes and haplotypes, and an association between SNPs and body composition parameters was analysed using four genetic models: dominant, recessive, codominant and overdominant mode of inheritance (MOI). The only statistically significant result in polymorphisms was found for rs3024505 in the over-dominant model with BMI (p = 0.04) and with fat % (p = 0.02). The haplo.score function showed an association between BMI and CCGTA (respectively) haplotype in the additive model (score = -2.00, p = 0.04) and in the dominant model (score = -2.30, p = 0.02). The obtained results indicate a statistically significant contribution of selected polymorphisms in the regulation of body weight in physically active individuals.
本研究的主要目的是调查白细胞介素10（IL-10）基因的5个多态性与身体活跃的年轻男性身体成分参数之间的关联。招募了131名年轻男性组成队列，并分析了以下单核苷酸多态性（SNP）：rs1518111、rs1878672、rs3024496、rs3024498和rs3024505。根据肥胖参数将受试者分组：体重指数（BMI）和体脂组织百分比（脂肪%）。对等位基因、基因型和单倍型进行了统计分析，并使用四种遗传模型：显性、隐性、共显性和超显性遗传模式（MOI）分析了SNP与身体成分参数之间的关联。在多态性方面，仅在rs3024505的超显性模型中发现与BMI（p = 0.04）和脂肪%（p = 0.02）有统计学显著结果。单倍型得分函数显示在加性模型（得分 = -2.00，p = 0.04）和显性模型（得分 = -2.30，p = 0.02）中，BMI与CCGTA单倍型之间存在关联。所得结果表明，所选IL-10多态性在调节身体活跃个体的体重方面有统计学显著贡献。
