在灵长类骨髓移植模型中可克隆的同种异体反应性宿主T细胞的证明。
Demonstration of clonable alloreactive host T cells in a primate model for bone marrow transplantation.
作者信息
Reisner Y, Ben-Bassat I, Douer D, Kaploon A, Schwartz E, Ramot B
出版信息
Proc Natl Acad Sci U S A. 1986 Jun;83(11):4012-5. doi: 10.1073/pnas.83.11.4012.
Abstract
The phenomenon of marrow rejection following supralethal radiochemotherapy was explained in the past mainly by non-T-cell mechanisms known to be resistant to high-dose irradiation. In the present study a low but significant number of radiochemoresistant-clonable T cells was found in the peripheral blood and spleen of Rhesus monkeys following the cytoreductive protocol used for treatment of leukemia patients prior to bone marrow transplantation. More than 95% of the clonable cells are concentrated in the spleen 5 days after transplant. The cells possess immune memory as demonstrated by the generation of alloreactive-specific cytotoxicity. The present findings suggest that host-versus-graft activity may be mediated by alloreactive T cells. It is hoped that elimination of such cells prior to bone marrow transplantation will increase the engraftment rate of HLA-nonidentical marrow in leukemia patients.
摘要
过去，超致死剂量放化疗后出现的骨髓排斥现象主要是由已知对高剂量辐射有抗性的非T细胞机制来解释的。在本研究中，在用白血病患者骨髓移植前用于细胞减灭的方案处理后，在恒河猴的外周血和脾脏中发现了数量虽少但显著的对放化疗有抗性且可克隆的T细胞。移植后5天，超过95%的可克隆细胞集中在脾脏中。这些细胞具有免疫记忆，同种异体反应性特异性细胞毒性的产生证明了这一点。目前的研究结果表明，宿主抗移植物活性可能由同种异体反应性T细胞介导。希望在骨髓移植前消除这些细胞将提高白血病患者中HLA不匹配骨髓的植入率。
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