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在转移性乳腺癌患者中鉴定具有预后价值的非典型循环肿瘤细胞。

Identification of Atypical Circulating Tumor Cells with Prognostic Value in Metastatic Breast Cancer Patients.

作者信息

Lopresti Alexia, Acquaviva Claire, Boudin Laurys, Finetti Pascal, Garnier Séverine, Aulas Anaïs, Liberatoscioli Maria Lucia, Cabaud Olivier, Guille Arnaud, de Nonneville Alexandre, Da Costa Quentin, Denicolai Emilie, Pakradouni Jihane, Goncalves Anthony, Birnbaum Daniel, Bertucci François, Mamessier Emilie

机构信息

Laboratory of Predictive Oncology, Cancer Research Center of Marseille, Inserm U1068-CNRS UMR7258-Université Aix-Marseille UM105, Label "Ligue Contre le Cancer", 13009 Marseille, France.

Sponsor Unit, Department of Clinical Research and Innovation, Institut Paoli-Calmettes, 13009 Marseille, France.

出版信息

Cancers (Basel). 2022 Feb 13;14(4):932. doi: 10.3390/cancers14040932.

DOI:10.3390/cancers14040932
PMID:35205679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8869799/
Abstract

Circulating tumor cells have a strong potential as a quasi-non-invasive tool for setting up a precision medicine strategy for cancer patients. Using a second-generation "filtration-based" technology to isolate CTCs, the Screencell™ technology (Sarcelles, France), we performed a large and simultaneous analysis of all atypical circulating tumor cells () isolated from the blood of metastatic breast cancer (mBC) patients. We correlated their presence with clinicopathological and survival data. We included 91 mBC patients from the PERMED-01 study. The median number of was 8.3 per mL of blood. Three subsets of , absent from controls, were observed in patients: single (), circulating tumor micro-emboli (), and giant-aCTCs (). The presence of was associated with shorter progression free survival and overall survival. This study highlights the heterogeneity of in mBC patients both at the cytomorphological and molecular levels. In addition, it suggests the usefulness of the subset as a prognostic factor and a potential stratification tool to treat late-stage mBC patients and improve their chances of benefiting from early clinical trials.

摘要

循环肿瘤细胞作为一种近乎非侵入性的工具，在为癌症患者制定精准医疗策略方面具有巨大潜力。我们使用第二代“基于过滤”的技术（法国萨尔塞勒的Screencell™技术）来分离循环肿瘤细胞（CTCs），对从转移性乳腺癌（mBC）患者血液中分离出的所有非典型循环肿瘤细胞进行了大规模同步分析。我们将它们的存在情况与临床病理和生存数据进行了关联。我们纳入了来自PERMED - 01研究的91例mBC患者。每毫升血液中CTCs的中位数为8.3个。在患者中观察到了对照组中不存在的三种CTCs亚群：单个CTCs（sCTCs）、循环肿瘤微栓子（CTM）和巨大非典型CTCs（giant-aCTCs）。CTCs的存在与无进展生存期和总生存期缩短相关。这项研究突出了mBC患者CTCs在细胞形态学和分子水平上的异质性。此外，它表明CTCs亚群作为一种预后因素以及治疗晚期mBC患者并提高他们从早期临床试验中获益机会的潜在分层工具的有用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/389a/8869799/8772d19e21dd/cancers-14-00932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/389a/8869799/fd9fc4915477/cancers-14-00932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/389a/8869799/767b9bd4f23c/cancers-14-00932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/389a/8869799/8772d19e21dd/cancers-14-00932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/389a/8869799/fd9fc4915477/cancers-14-00932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/389a/8869799/767b9bd4f23c/cancers-14-00932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/389a/8869799/8772d19e21dd/cancers-14-00932-g003.jpg

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本文引用的文献

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Cancer associated macrophage-like cells and prognosis of esophageal cancer after chemoradiation therapy.
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Cell Fusion and Syncytia Formation in Cancer.癌细胞的融合与合胞体形成。
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Cancers (Basel). 2023 Jul 22;15(14):3725. doi: 10.3390/cancers15143725.
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