Ogurtsov R P, Zheleznikova G F
Zh Mikrobiol Epidemiol Immunobiol. 1978 Mar(3):45-50.
The authors studied the influence of the serum obtained at various periods after the administration of interferon inductors (New castle disease virus, amino ethylisothiouronium, E. coli endotoxin) on the rate of rejection of the skin or cell transplant of mice C3H and CBA, and also CC57Br. The allogenous skin transplant perished more rapidly; there was also an acceleration of elimination of allogenous lymphoid cells, suppression of colony formation by the cells of allogenous bone marrow in the spleen of the irradiated recipient in administration of the serum obtained at the period of maximal content of interferon induced by the Newcastle disease virus and by amino ethylisothiouronium. The cytotoxic activity of lymphocytes of mice CC57Br against the allogenous target cells rose in the presence of these sera. The serum containing interferon induced with E. coli endotoxin failed to influence the rate of the allotransplant rejection and did not increase the cytotoxic activity of lymphocytes.
作者研究了在给予干扰素诱导剂（新城疫病毒、氨基乙基异硫脲、大肠杆菌内毒素）后不同时期获得的血清对C3H、CBA以及CC57Br小鼠皮肤或细胞移植排斥率的影响。同种异体皮肤移植更快死亡；在给予由新城疫病毒和氨基乙基异硫脲诱导产生的干扰素含量最高时期获得的血清时，还出现了同种异体淋巴细胞清除加速、受照射受体脾脏中同种异体骨髓细胞集落形成受到抑制的情况。在这些血清存在的情况下，CC57Br小鼠淋巴细胞对同种异体靶细胞的细胞毒性活性升高。含有由大肠杆菌内毒素诱导产生的干扰素的血清未能影响同种异体移植的排斥率，也未增加淋巴细胞的细胞毒性活性。
