Skurkovich S V, Klinova E G, Aleksandrovskaya I M, Levina N V, Arkhipova N A, Bulicheva T I
Immunology. 1973 Aug;25(2):317-22.
It is assumed that interferon is a necessary component of the formation of immunological reactivity. At the same time interferon may serve as a factor stimulating immunity as a whole. Administration of interferon to mice, recipients of skin allografts, brings about acceleration of rejection process and stimulation of the cytotoxic activity of lymphocytes of mice towards target cells. With the repeated transplantations to mice treated with interferon in the first grafting, acceleration of rejection of new grafts (the `second set' phenomenon) is observed. Intrasplenic inoculation of interferon to mice at the time of antigen administration results in intensified plasma cell reaction in the spleens.
据推测，干扰素是免疫反应形成的必要组成部分。同时，干扰素可能作为一个整体刺激免疫的因素。给接受皮肤同种异体移植的小鼠注射干扰素，会加速排斥过程，并刺激小鼠淋巴细胞对靶细胞的细胞毒性活性。在首次移植时用干扰素处理过的小鼠再次移植时，会观察到新移植组织排斥加速（“二次免疫”现象）。在给小鼠注射抗原时进行脾内注射干扰素，会导致脾脏中浆细胞反应增强。
