Burkhardt B R, Dempsey P D, Schnur P L, Tofield J J
Plast Reconstr Surg. 1986 Jun;77(6):919-32.
In a prospective, random, double-blind, and concurrently controlled clinical study of 124 patients having augmentation mammaplasty, using multiple independent subjective judges as well as objective compressibility measurements, the use of a variety of local antibacterials in or around inflatable retromammary prosthetic implants reduced the early postoperative onset of class III to IV capsular contracture by sevenfold (85 percent) and the final incidence by more than half (50 percent) (p less than 0.01). We believe this study provides the most unequivocal evidence to date that the cause of capsular contracture in retromammary augmentation is periprosthetic bacterial contamination. Irrigation with a 5 percent povidone-iodine (50 percent Betadine) solution was as effective as other techniques and is currently our procedure of choice.
在一项针对124例行隆乳术患者的前瞻性、随机、双盲及同期对照临床研究中，通过多名独立主观评判者以及客观的可压缩性测量发现，在可充气的乳腺后假体植入物内或其周围使用多种局部抗菌药物，可使术后早期III至IV级包膜挛缩的发生率降低至原来的七分之一（85%），最终发生率降低超过一半（50%）（p<0.01）。我们认为，这项研究提供了迄今为止最明确的证据，表明乳腺后隆乳术中包膜挛缩的原因是假体周围细菌污染。用5%聚维酮碘（50%碘伏）溶液冲洗与其他技术同样有效，目前是我们的首选方法。
