EPI@LUND (Epidemiology, Population Studies, and Infrastructures at Lund University), Division of Occupational and Environmental Medicine, Lund University, 223 62 Lund, Sweden.
Epidemiology, Division of Occupational and Environmental Medicine, Lund University, 223 63 Lund, Sweden.
Int J Environ Res Public Health. 2022 Feb 18;19(4):2385. doi: 10.3390/ijerph19042385.
In 2013, the drinking water for one-third of the households in Ronneby, Sweden, was found to be contaminated by perfluorinated alkyl substances (PFAS, >10,000 ng/L) from Aqueous Film Forming Foam (AFFF). In utero PFAS exposure can influence birth weight, but little is known about the effects at very high levels. This study aimed to examine the association between in utero PFAS exposure and birth weight. Infants with mothers from Ronneby exposed to contaminated water at home (high exposure) and infants with mothers from Ronneby not exposed to contaminated water at home (low exposure) were compared to infants with mothers from Blekinge county excluding Ronneby (referents). All infants born in Blekinge county 1995-2013 were included ( = 30,360). Differences in birth weight were only seen among infants born after 2005. For boys, Ronneby high exposure had a lower mean birth weight than referents (-54 g, 95% CI -97; -11). For girls, Ronneby high exposure had a higher mean birth weight than referents (47 g, 95% CI 4; 90). There were no differences in birth weight between referents and Ronneby low exposure. In conclusion, high exposure to PFAS may influence birth weight in a sex-specific way, although the effect estimates were relatively small.
2013 年，瑞典隆比市三分之一的家庭饮用水被发现受到来自水成膜泡沫（AFFF）的全氟烷基物质（PFAS，>10000ng/L）的污染。PFAS 在子宫内的暴露会影响出生体重，但对于极高水平的暴露的影响知之甚少。本研究旨在探讨子宫内 PFAS 暴露与出生体重之间的关系。与来自隆比市且家中饮用水受到污染（高暴露）的母亲的婴儿以及来自隆比市且家中饮用水未受到污染（低暴露）的母亲的婴儿相比，来自不包括隆比市的布莱金厄县的母亲的婴儿（对照）。所有在 1995-2013 年出生于布莱金厄县的婴儿均被纳入（=30360）。仅在 2005 年后出生的婴儿中观察到出生体重的差异。对于男孩，隆比市高暴露组的平均出生体重低于对照组（-54g，95%CI-97；-11）。对于女孩，隆比市高暴露组的平均出生体重高于对照组（47g，95%CI4；90）。对照组和隆比市低暴露组之间的出生体重没有差异。总之，PFAS 的高暴露可能以性别特异性的方式影响出生体重，尽管效应估计值相对较小。
