School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
London School of Hygiene and Tropical Medicine, London, UK.
Environ Health Perspect. 2020 Jul;128(7):77004. doi: 10.1289/EHP6785. Epub 2020 Jul 10.
Firefighting foam-contaminated ground water, which contains high levels of perfluoroalkyl substances (PFAS), is frequently found around airports. In 2018 it was detected that employees at a municipal airport in northern Sweden had been exposed to high levels of short-chain PFAS along with legacy PFAS (i.e., PFOA, PFHxS, and PFOS) through drinking water.
In this study, we aimed to describe the PFAS profile in drinking water and biological samples (paired serum and urine) and to estimate serum half-lives of the short-chain PFAS together with legacy PFAS.
Within 2 weeks after provision of clean water, blood sampling was performed in all 26 airport employees. Seventeen of them were then followed up monthly for 5 months. PFHxA, PFHpA, PFBS, PFPeS, and PFHpS together with legacy PFAS in water and biological samples were quantified using LC/MS/MS. Half-lives were estimated by assuming one compartment, first-order elimination kinetics.
The proportions of PFHxA, PFHpA, and PFBS were higher in drinking water than in serum. The opposite was found for PFHxS and PFOS. The legacy PFAS accounted for about 50% of total PFAS in drinking water and 90% in serum. Urinary PFAS levels were very low compared with serum. PFBS showed the shortest half-life {average 44 d [95% confidence interval (CI): 37, 55 d]}, followed by PFHpA [62 d (95% CI: 51, 80 d)]. PFPeS and PFHpS showed average half-lives as 0.63 and 1.46 y, respectively. Branched PFOS isomers had average half-lives ranging from 1.05 to 1.26 y for different isomers. PFOA, PFHxS, and linear PFOS isomers showed average half-lives of 1.77, 2.87, and 2.93 y, respectively.
A general pattern of increasing half-lives with increasing chain length was observed. Branched PFOS isomers had shorter half-lives than linear PFOS isomers. https://doi.org/10.1289/EHP6785.
消防泡沫污染的地下水含有高水平的全氟烷基物质（PFAS），经常在机场周围发现。2018 年，瑞典北部一个市政机场的员工发现，他们通过饮用水接触到了高水平的短链 PFAS 以及传统的 PFAS（即 PFOA、PFHxS 和 PFOS）。
在这项研究中，我们旨在描述饮用水和生物样本（配对的血清和尿液）中的 PFAS 特征，并估计短链 PFAS 与传统 PFAS 的血清半衰期。
在提供清洁水后的两周内，对所有 26 名机场员工进行了采血。其中 17 人随后每月随访 5 个月。使用 LC/MS/MS 定量测定水中和生物样本中的 PFHxA、PFHpA、PFBS、PFPeS 和 PFHpS 以及传统的 PFAS。半衰期通过假设一个隔室、一级消除动力学来估计。
饮用水中 PFHxA、PFHpA 和 PFBS 的比例高于血清，而 PFHxS 和 PFOS 则相反。饮用水中传统的 PFAS 占总 PFAS 的 50%左右，而血清中则占 90%左右。与血清相比，尿液中的 PFAS 水平非常低。PFBS 的半衰期最短{平均 44 d [95%置信区间（CI）：37，55 d]}，其次是 PFHpA[62 d（95%CI：51，80 d）]。PFPeS 和 PFHpS 的平均半衰期分别为 0.63 和 1.46 年。不同异构体的支链 PFOS 异构体的平均半衰期范围为 1.05 至 1.26 年。PFOA、PFHxS 和线性 PFOS 异构体的平均半衰期分别为 1.77、2.87 和 2.93 年。
观察到随着链长的增加半衰期逐渐增加的一般模式。支链 PFOS 异构体的半衰期短于线性 PFOS 异构体。https://doi.org/10.1289/EHP6785.
