Stuchtey Fidelis Christin, Block Andrea, Osei Francis, Wippert Pia-Maria
Department of Human Medicine, Paracelsus Medical Private University, 5020 Salzburg, Austria.
Medical Sociology and Psychobiology, Department of Health and Physical Activity, University of Potsdam, 14469 Potsdam, Germany.
Healthcare (Basel). 2022 Feb 9;10(2):333. doi: 10.3390/healthcare10020333.
Studies have revealed mixed results on how antidepressant drugs affect lipid profiles of patients with major depression disorder (MDD). Even less is known about how patients respond to a switch of antidepressant medication with respect to their metabolic profile. For this, effects of a switch in antidepressants medication on lipid markers were studied in MDD patients. 15 participants (females = 86.67%; males = 13.33%; age: 49.45 ± 7.45 years) with MDD and a prescribed switch in their antidepressant medication were recruited at a psychosomatic rehabilitation clinic. Participants were characterized (with questionnaires and blood samples) at admission to the rehabilitation clinic (baseline, T0) and followed up with a blood sample two weeks (T1) later. HDL, LDL, total cholesterol, and triglycerides were determined (T0), and their change analyzed (Wilcoxon test) at follow up (T1). Decrements in HDL ( = 0.041), LDL ( < 0.001), and total cholesterol ( < 0.001) were observed two weeks after a switch in antidepressant medication. Triglycerides showed no difference ( = 0.699). Overall, LDL, HDL, and total cholesterol are affected by a change in antidepressant drugs in patients with MDD. These observations are of clinical relevance for medical practitioners in the planning and management of treatment strategies for MDD patients.
关于抗抑郁药物如何影响重度抑郁症（MDD）患者的血脂谱，研究结果不一。对于MDD患者在更换抗抑郁药物时其代谢状况如何变化，我们了解得更少。为此，我们研究了更换抗抑郁药物对MDD患者血脂指标的影响。在一家身心康复诊所招募了15名患有MDD且正在更换抗抑郁药物的参与者（女性占86.67%；男性占13.33%；年龄：49.45±7.45岁）。在康复诊所入院时（基线，T0）对参与者进行特征描述（通过问卷调查和采集血样），并在两周后（T1）采集血样进行随访。测定（T0）高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、总胆固醇和甘油三酯，并在随访时（T1）分析其变化（Wilcoxon检验）。更换抗抑郁药物两周后，观察到HDL（ = 0.041）、LDL（ < 0.001）和总胆固醇（ < 0.001）下降。甘油三酯无差异（ = 0.699）。总体而言，MDD患者更换抗抑郁药物会影响LDL、HDL和总胆固醇。这些观察结果对医生在规划和管理MDD患者的治疗策略方面具有临床意义。
