García-Fernández Lorena, Romero-Ferreiro Verónica, Sánchez-Pastor Luis, Dompablo Mónica, Martínez-Gras Isabel, Espejo-Saavedra Juan Manuel, Rentero David, Aparicio Ana Isabel, Alvarez-Mon Miguel Angel, Lahera Guillermo, Lee Jimmy, Santos Jose Luis, Rodriguez-Jimenez Roberto
Clinical Medicine Department, Universidad Miguel Hernández, 03550 Alicante, Spain.
Psychiatry Department, Hospital Universitario de San Juan, 03550 Alicante, Spain.
J Clin Med. 2022 Feb 14;11(4):983. doi: 10.3390/jcm11040983.
Negative symptoms are not considered a unitary construct encompassing two different domains, diminished expression, and avolition-apathy. The aim of this study was to explore the relationships between each domain and psychosocial functioning and quality of life in people with a first psychotic episode of schizophrenia. In total, 61 outpatients were assessed with the Clinical Assessment Interview for Negative Symptoms (CAINS), The Functioning Assesment Short Test (FAST) and The Quality of Life Scale (QLS). The mean global score for CAINS was 21.5 (SD: 15.6), with a CAINS Avolition-Apathy (MAP) score of 17.0 (SD: 11.8), and CAINS Diminished Expression (EXP) score of 4.5 (SD: 5.0). The mean FAST score was 31.9 (SD: 18.9), and 41.1 (SD: 17.9) for QLS. Linear regression analysis revealed a significant (F(4,53) = 15.65, < 0.001) relationship between MAP and EXP CAINS' score and FAST score. CAINS-MAP was more predictive of FAST scores (β = 0.44, = 0.001) than CAINS-EXP (β = 0.37, = 0.007). Linear regression analysis for QLS revealed a significant model (F(4,56) = 29.29, < 0.001). The standardized regression weight for the CAINS-MAP was around three times greater (β = -0.63, < 0.001) than for CAINS-EXP (β = -0.24, = 0.024). The two different domains are associated differently with functionality and quality of life.
阴性症状并非一个包含两个不同领域（即表达减少和意志缺乏-淡漠）的单一结构。本研究的目的是探讨精神分裂症首次发作患者中每个领域与心理社会功能及生活质量之间的关系。总共61名门诊患者接受了阴性症状临床评估访谈（CAINS）、功能评估简短测试（FAST）和生活质量量表（QLS）的评估。CAINS的总体平均得分为21.5（标准差：15.6），其中CAINS意志缺乏-淡漠（MAP）得分为17.0（标准差：11.8），CAINS表达减少（EXP）得分为4.5（标准差：5.0）。FAST的平均得分为31.9（标准差：18.9），QLS的平均得分为41.1（标准差：17.9）。线性回归分析显示，MAP和EXP的CAINS得分与FAST得分之间存在显著关系（F(4,53) = 15.65，< 0.001）。与CAINS-EXP（β = 0.37， = 0.007）相比，CAINS-MAP对FAST得分的预测性更强（β = 0.44， = 0.001）。对QLS进行的线性回归分析显示出一个显著模型（F(4,56) = 29.29，< 0.001）。CAINS-MAP的标准化回归权重（β = -0.63，< 0.001）约为CAINS-EXP（β = -0.24， = 0.024）的三倍。这两个不同领域与功能和生活质量的关联方式不同。
