Hofauer Benedikt, Kirschstein Lara, Graf Simone, Strassen Ulrich, Johnson Felix, Zhu Zhaojun, Knopf Andreas
Department of Otorhinolaryngology/Head and Neck Surgery, Klinikum Rechts der Isar, Technical University of Munich, 80538 Munich, Germany.
Department of Otorhinolaryngology/Head and Neck Surgery, University Medical Center Freiburg, University of Freiburg, 79106 Freiburg, Germany.
J Clin Med. 2022 Feb 18;11(4):1081. doi: 10.3390/jcm11041081.
Xerostomia and keratoconjunctivitis sicca are the main symptoms of Sjögren's syndrome. Often patients also suffer from laryngeal complaints, but there is a lack of specific treatment options. The aim of this study was to evaluate the effect of a liposomal inhalation therapy. Patients with Sjögren's syndrome were included and received a two-month period of liposomal inhalation therapy. The effect was evaluated by standardized questionnaires (patient-reported indices) and measurement of unstimulated whole salivary flow and glandular stiffness. Forty-five patients were included in this study. A comparison of baseline and therapeutic values demonstrated a significant improvement of the EULAR Sjögren's syndrome patient reported index (ESSPRI) with a baseline of 5.0 ± 2.1 and a therapeutic value of 4.1 ± 2.4 ( = 0.012). This improvement was mainly based on the item on dryness within this score. Overall, the therapy was well tolerated. In conclusion, an inhalative application of liposomes had a beneficial effect on the reported dryness in patients with Sjögren's syndrome. A first insight into the effect of inhalation therapy on laryngeal symptoms could thus be obtained and at the same time the basis was created on which case calculations can be carried out in the future.
口干症和干燥性角结膜炎是干燥综合征的主要症状。患者常常还伴有喉部不适，但缺乏特定的治疗方案。本研究的目的是评估脂质体吸入疗法的效果。纳入干燥综合征患者并给予为期两个月的脂质体吸入治疗。通过标准化问卷（患者报告指标）以及测量非刺激性全唾液流量和腺体硬度来评估疗效。本研究纳入了45名患者。基线值与治疗后值的比较显示，欧洲抗风湿病联盟干燥综合征患者报告指数（ESSPRI）有显著改善，基线值为5.0±2.1，治疗后值为4.1±2.4（ = 0.012）。这种改善主要基于该评分中关于干燥的项目。总体而言，该治疗耐受性良好。总之，脂质体吸入应用对干燥综合征患者报告的干燥症状有有益影响。由此可以初步了解吸入疗法对喉部症状的效果，同时也为未来进行病例计算奠定了基础。
