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炎症性疾病中的微血管病变——下肢手术策略

Microangiopathy in Inflammatory Diseases-Strategies in Surgery of the Lower Extremity.

作者信息

Biehl Christoph, Biehl Lotta, Tarner Ingo Helmut, Müller-Ladner Ulf, Heiss Christian, Heinrich Martin

机构信息

Department of Trauma, Hand and Reconstructive Surgery, University Hospital Giessen, 35392 Giessen, Germany.

Medical Faculty Heidelberg, Heidelberg University, 69117 Heidelberg, Germany.

出版信息

Life (Basel). 2022 Jan 28;12(2):200. doi: 10.3390/life12020200.

DOI:10.3390/life12020200
PMID:35207487
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8876644/
Abstract

BACKGROUND

Patients with an inflammatory disease frequently develop chronic angiopathy of the capillaries. Due to this pathology, there is an increased rate of complications in lower extremity surgical procedures. It is not uncommon for microangiopathic wound healing disorders to cause deep infections and fistulas, which lead to prolonged courses and hospitalizations. In addition, adhesions and ossifications of the contractile elements occur regularly. This sometimes results in serious limitations of the mobility of the patients. The study aims to present the results of a combination of vacuum and physical therapy.

PATIENT AND METHODS

A retrospective study of six patients with systemic sclerosis undergoing joint-related procedures of the lower extremity between 2015 and 2020 was performed. In addition to characterization of the patients and therapy, special attention was paid to cutaneous wound healing, affection of the fascia and displacement layers, and sclerosis of the muscle and tendon insertion.

RESULTS

The characterized structures (skin, tendon, fascia) show pathological changes at the microangiopathic level, which are associated with delayed healing and less physical capacity. Early suture removal regularly results in secondary scar dehiscence. With a stage-adapted vacuum therapy with sanitation of the deep structures and later on a dermal vacuum system, healing with simultaneous mobilization of the patients could be achieved in our patient cohort.

CONCLUSION

In the case of necessary interventions on the lower extremity, such as trauma surgery, additional decongestive measures in the sense of regular and sustained lymphatic therapy and adapted physiotherapy are indispensable.

摘要

背景

炎症性疾病患者常发生毛细血管慢性血管病变。由于这种病理状况,下肢外科手术的并发症发生率增加。微血管性伤口愈合障碍导致深部感染和瘘管并不罕见,这会导致病程延长和住院时间延长。此外,收缩元件的粘连和骨化经常发生。这有时会导致患者活动严重受限。本研究旨在介绍负压与物理治疗相结合的结果。

患者与方法

对2015年至2020年间接受下肢关节相关手术的6例系统性硬化症患者进行回顾性研究。除了对患者和治疗方法进行描述外,还特别关注皮肤伤口愈合、筋膜和移位层的病变以及肌肉和肌腱附着处的硬化情况。

结果

所描述的结构(皮肤、肌腱、筋膜)在微血管水平上显示出病理变化,这与愈合延迟和身体能力下降有关。早期拆线经常导致继发性瘢痕裂开。通过采用适应不同阶段的负压疗法对深部结构进行清创,随后使用真皮负压系统,我们的患者队列实现了愈合的同时患者的活动能力也得到了恢复。

结论

在进行下肢必要干预(如创伤手术)时,定期且持续的淋巴治疗意义上的额外消肿措施以及适应性物理治疗是必不可少的。

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本文引用的文献

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J Scleroderma Relat Disord. 2020 Oct;5(3):224-230. doi: 10.1177/2397198320913689. Epub 2020 Apr 27.
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Current Concepts on the Pathogenesis of Systemic Sclerosis.系统性硬化症发病机制的现代概念。
Clin Rev Allergy Immunol. 2023 Jun;64(3):262-283. doi: 10.1007/s12016-021-08889-8. Epub 2021 Sep 6.
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Hematological Manifestations among Patients with Rheumatic Diseases.
风湿性疾病患者的血液学表现。
Acta Haematol. 2021;144(4):403-412. doi: 10.1159/000511759. Epub 2020 Nov 20.
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Haematological abnormalities in systemic sclerosis.系统性硬化症中的血液学异常
Reumatologia. 2020;58(3):162-166. doi: 10.5114/reum.2020.96655. Epub 2020 Jun 29.
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[Physical activity, exercise and nutrition in rheumatism : Adjuvant treatment options for inflammatory-rheumatic diseases].[风湿病中的身体活动、运动与营养:炎症性风湿疾病的辅助治疗选择]
Orthopade. 2019 Nov;48(11):917-926. doi: 10.1007/s00132-019-03808-4.
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Thrombotic Microangiopathies with Rheumatologic Involvement.伴有风湿性疾病累及的血栓性微血管病
Rheum Dis Clin North Am. 2018 Nov;44(4):635-649. doi: 10.1016/j.rdc.2018.06.010. Epub 2018 Sep 7.
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From Localized Scleroderma to Systemic Sclerosis: Coexistence or Possible Evolution.从局限性硬皮病到系统性硬化症:共存还是可能的演变
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