Maranini Beatrice, Ciancio Giovanni, Ferracin Manuela, Cultrera Rosario, Negrini Massimo, Sabbioni Silvia, Govoni Marcello
Rheumatology Unit, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, 40138 Bologna, Italy.
Life (Basel). 2022 Feb 15;12(2):288. doi: 10.3390/life12020288.
The current SARS-CoV-2 pandemic has emerged as an international challenge with strong medical and socioeconomic impact. The spectrum of clinical manifestations of SARS-CoV-2 is wide, covering asymptomatic or mild cases up to severe and life-threatening complications. Critical courses of SARS-CoV-2 infection are thought to be driven by the so-called "cytokine storm", derived from an excessive immune response that induces the release of proinflammatory cytokines and chemokines. In recent years, non-coding RNAs (ncRNAs) emerged as potential diagnostic and therapeutic biomarkers in both inflammatory and infectious diseases. Therefore, the identification of SARS-CoV-2 miRNAs and host miRNAs is an important research topic, investigating the host-virus crosstalk in COVID-19 infection, trying to answer the pressing question of whether miRNA-based therapeutics can be employed to tackle SARS-CoV-2 complications. In this review, we aimed to directly address ncRNA role in SARS-CoV-2-immune system crosstalk upon COVID-19 infection, particularly focusing on inflammatory pathways and cytokine storm syndromes.
当前的新型冠状病毒肺炎大流行已成为一项具有重大医学和社会经济影响的国际挑战。新型冠状病毒的临床表现范围广泛，涵盖无症状或轻症病例，直至严重及危及生命的并发症。新型冠状病毒感染的危急病程被认为是由所谓的“细胞因子风暴”驱动的，这种风暴源于过度的免疫反应，可诱导促炎细胞因子和趋化因子的释放。近年来，非编码RNA（ncRNA）在炎症性疾病和感染性疾病中均成为潜在的诊断和治疗生物标志物。因此，鉴定新型冠状病毒的微小RNA（miRNA）和宿主miRNA是一个重要的研究课题，旨在研究新型冠状病毒肺炎感染中宿主与病毒的相互作用，试图回答能否采用基于miRNA的疗法来应对新型冠状病毒并发症这一紧迫问题。在本综述中，我们旨在直接探讨ncRNA在新型冠状病毒肺炎感染时新型冠状病毒与免疫系统相互作用中的作用，尤其关注炎症途径和细胞因子风暴综合征。
