Kim Chan-Hee, Lee Seon-Heui
Artificial Kidney Team, Incheon Sejong Hospital, Incheon 21080, Korea.
Department of Nursing Science, College of Nursing, Gachon University, Incheon 21936, Korea.
Life (Basel). 2022 Feb 18;12(2):308. doi: 10.3390/life12020308.
(1) Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and endocrine disorders among women of reproductive age. Previous studies have employed lifestyle interventions to manage anovulatory infertility and endocrine disorders. However, the effect of lifestyle interventions on the metabolic index remains ambiguous; (2) Methods: Data were obtained through a systematic search of the Ovid-Medline, Ovid-EMBASE, and Cochrane Library databases. Two reviewers independently reviewed the literature in two stages. A consensus was achieved through discussions regarding the final selection of the literature; (3) Results: This study observed that the group that underwent lifestyle modifications displayed significant improvement in reproductive function compared to the control group. Combination therapy with diet and exercise resulted in improved fasting insulin levels, compared to monotherapy with diet or exercise. Moreover, moderate weight loss (a minimum of 5%) resulted in an improved metabolic index. The subgroup analysis revealed that the group that underwent lifestyle modifications had a significantly higher number of patients with improved menstrual cycles, compared to the control groups; (4) Conclusions: Lifestyle modification using combination therapy is a promising therapeutic approach that can be employed in the management of PCOS patients with obesity. This scenario warrants further studies with larger sample sizes to develop ideal treatment protocols.
(1) 背景：多囊卵巢综合征（PCOS）是育龄期女性无排卵性不孕和内分泌紊乱的最常见原因。以往研究采用生活方式干预来治疗无排卵性不孕和内分泌紊乱。然而，生活方式干预对代谢指标的影响仍不明确；(2) 方法：通过系统检索Ovid-Medline、Ovid-EMBASE和Cochrane图书馆数据库获取数据。两名研究者分两个阶段独立对文献进行评审。通过讨论达成关于文献最终选择的共识；(3) 结果：本研究观察到，与对照组相比，接受生活方式改变的组生殖功能有显著改善。与单纯饮食或运动疗法相比，饮食和运动联合疗法可降低空腹胰岛素水平。此外，适度体重减轻（至少5%）可改善代谢指标。亚组分析显示，与对照组相比，接受生活方式改变的组月经周期改善的患者数量显著更多；(4) 结论：采用联合疗法进行生活方式改变是一种有前景的治疗方法，可用于治疗肥胖的PCOS患者。这种情况需要进一步开展更大样本量的研究以制定理想的治疗方案。
