Department of Clinical Neurosciences, Colentina Clinical Hospital Neurology Division, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Laboratory of Neurosciences and Experimental Myology, Victor Babeș National Institute of Pathology, 050096 Bucharest, Romania.
Medicina (Kaunas). 2022 Feb 6;58(2):245. doi: 10.3390/medicina58020245.
: Parkinson's disease (PD) is a prevalent neurodegenerative condition responsible for progressive motor and non-motor symptoms. Currently, no prophylactic or disease-modifying interventions are available. Uric acid (UA) is a potent endogenous antioxidant, resulting from purine metabolism. It is responsible for about half of the antioxidant capacity of the plasma. Increasing evidence suggests that lower serum UA levels are associated with an increased risk of developing PD and with faster disease progression. : We conducted an electronic medical record database study to investigate the associations between UA levels and different characteristics of PD. : Out of 274 datasets from distinct patients with PD, 49 complied with the predefined inclusion and exclusion criteria. Lower UA levels were significantly associated with the severity of parkinsonism according to the Hoehn and Yahr stage (r = 0.488, = 0.002), with the motor complications of long-term dopaminergic treatment (r = 0.333, = 0.027), and with the presence of neurocognitive impairment (r = 0.346, = 0.021). : Oxidative stress is considered a key player in the etiopathogenesis of PD, therefore the involvement of lower UA levels in the development and progression of PD is plausible. Data on the potential therapeutic roles of elevating serum UA (e.g., by precursor administration or diet manipulation) are scarce, but considering the accumulating epidemiological evidence, the topic warrants further research.
帕金森病（PD）是一种常见的神经退行性疾病，可导致进行性运动和非运动症状。目前，尚无预防性或疾病修饰干预措施。尿酸（UA）是一种有效的内源性抗氧化剂，来源于嘌呤代谢。它负责血浆抗氧化能力的约一半。越来越多的证据表明，血清 UA 水平较低与 PD 的发病风险增加以及疾病进展更快有关。
我们进行了一项电子病历数据库研究，以调查 UA 水平与 PD 不同特征之间的关联。
在来自不同 PD 患者的 274 个数据集，符合预先设定的纳入和排除标准的有 49 个。UA 水平较低与 Hoehn 和 Yahr 分期（r = 0.488， = 0.002）所示的帕金森病严重程度显著相关，与长期多巴胺治疗的运动并发症（r = 0.333， = 0.027）相关，与神经认知障碍的存在（r = 0.346， = 0.021）相关。
氧化应激被认为是 PD 发病机制中的一个关键因素，因此 UA 水平较低参与 PD 的发生和发展是合理的。关于升高血清 UA 的潜在治疗作用的数据（例如，通过前体给药或饮食干预）很少，但考虑到累积的流行病学证据，这个话题值得进一步研究。
