Department of Otolaryngology Head and Neck Surgery and Maxillofacial Surgery, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv 642 3906, Israel.
Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv 642 3906, Israel.
Medicina (Kaunas). 2022 Feb 10;58(2):263. doi: 10.3390/medicina58020263.
: This retrospective cohort study aimed to compare three postoperative antibiotic protocols of different durations on surgical-site-infection (SSI) rates following orthognathic surgery for the correction of jaw deformities. : An analysis on data collected from the medical files of 209 patients who underwent orthognathic surgery between 2010 and 2019 was conducted. The patients were divided into three groups according to the postoperative antibiotic protocol-Group 1 (24 h), Group 2 (2-3 days), and Group 3 (>3 days). Dependent and independent variables were collected, analyzed, and compared between the three groups. : Group 1 included 30 patients (14.3%), Group 2 included 123 patients (58.9%), and Group 3 included 56 patients (26.8%). The vast majority of the postoperative antibiotics were amoxicillinand clavulanic acid (87.1%). The duration of the surgery and the use of a feeding tube were significantly different between Groups 1 and 3 ( < 0.001 and = 0.005, respectively). There was no significant difference in SSI rates between the three groups ( = 0.642). The use of antibiotics beyond the immediate postoperative period provides no increased benefit regarding infection prevention. : In young and healthy patients undergoing orthognathic surgery, a 24hregimen of postoperative antibiotics may be sufficient.
本回顾性队列研究旨在比较三种不同持续时间的术后抗生素方案对颌骨畸形正颌手术后手术部位感染（SSI）发生率的影响。对 2010 年至 2019 年间接受正颌手术的 209 名患者的病历数据进行了分析。根据术后抗生素方案将患者分为三组：组 1（24 小时）、组 2（2-3 天）和组 3（>3 天）。收集、分析并比较了三组之间的依赖和独立变量。组 1 包括 30 名患者（14.3%），组 2 包括 123 名患者（58.9%），组 3 包括 56 名患者（26.8%）。术后抗生素绝大多数为阿莫西林克拉维酸（87.1%）。组 1 和组 3 之间的手术持续时间和使用喂养管存在显著差异（<0.001 和=0.005）。三组之间 SSI 发生率无显著差异（=0.642）。在接受正颌手术的年轻健康患者中，术后使用抗生素 24 小时可能已足够。
