Kepler University Hospital Linz, Institute of Laboratory Medicine, Linz, Austria.
Medical University of Vienna, Vienna, Austria.
Biochem Med (Zagreb). 2022 Feb 15;32(1):011002. doi: 10.11613/BM.2022.011002.
Creatinine and estimated glomerular filtration rate (eGFR) are first-line laboratory parameters in the diagnosis of various renal diseases. In recent decades, cystatin C (cysC) has furthered the laboratory repertoire regarding renal status assessment and has been implemented in many clinical guidelines. Accordingly, with the establishment of cysC as a renal routine biomarker, further opportunities for assessing eGFR have been attained. Nevertheless, various limitations are still associated with cysC and creatinine analysis. Preanalytical errors could cause false results in both biomarkers. In our case, we were confronted with implausibly elevated creatinine levels due to preanalytical errors.
肌酐和估算肾小球滤过率（eGFR）是诊断各种肾脏疾病的一线实验室参数。在最近几十年中，胱抑素 C（cysC）进一步丰富了评估肾脏状态的实验室检测手段，并已被纳入许多临床指南中。因此，随着 cysC 作为常规肾脏生物标志物的确立，评估 eGFR 的机会也有所增加。然而，cysC 和肌酐分析仍然存在各种局限性。分析前误差可能导致这两种生物标志物的结果出现假阳性。在我们的案例中，由于分析前误差，导致肌酐水平升高得令人难以置信。
