Funamoto Masafumi, Shimizu Kana, Sunagawa Yoichi, Katanasaka Yasufumi, Miyazaki Yusuke, Komiyama Maki, Yamakage Hajime, Satoh-Asahara Noriko, Takahashi Yuko, Wada Hiromichi, Hasegawa Koji, Morimoto Tatsuya
Division of Molecular Medicine, School of Pharmaceutical Sciences, University of Shizuoka Shizuoka Japan.
Clinical Research Institute, National Hospital Organization Kyoto Medical Center Kyoto Japan.
Circ Rep. 2019 Nov 30;1(12):623-627. doi: 10.1253/circrep.CR-19-0052.
Smoking exerts detrimental effects during the progression of atherosclerotic vascular disease. Serum cystatin C is useful in the evaluation of early renal dysfunction and serves as a cardiovascular prognostic marker. This study measured changes in serum cystatin C after smoking cessation (SC). In this study, patients who visited the SC clinic for the first time and succeeded in SC for 1 year were enrolled. In the entire cohort of 86 patients, body mass index (BMI, P<0.001) and waist circumference (WC, P<0.001) increased significantly at 3 months after SC compared with baseline. These values were further increased significantly (BMI, P<0.001; WC, P<0.001) from 3 months to 1 year after SC. Serum cystatin C decreased significantly at 3 months (P=0.045) after SC, and remained unchanged (P=0.482) from 3 months to 1 year after SC. Percent change from baseline to 3 months after SC in serum cystatin C was correlated with the percent change in serum monocyte chemoattractant protein 1 (P=0.047). Serum cystatin C, a marker of chronic kidney disease, was significantly reduced at 3 months after SC.
吸烟在动脉粥样硬化性血管疾病进展过程中会产生有害影响。血清胱抑素C有助于评估早期肾功能不全，并可作为心血管疾病的预后标志物。本研究测量了戒烟后血清胱抑素C的变化。在本研究中，纳入了首次前往戒烟诊所并成功戒烟1年的患者。在86例患者的整个队列中，与基线相比，戒烟后3个月时体重指数（BMI，P<0.001）和腰围（WC，P<0.001）显著增加。从戒烟后3个月到1年，这些值进一步显著增加（BMI，P<0.001；WC，P<0.001）。戒烟后3个月时血清胱抑素C显著降低（P=0.045），从戒烟后3个月到1年保持不变（P=0.482）。戒烟后3个月血清胱抑素C相对于基线的变化百分比与血清单核细胞趋化蛋白1的变化百分比相关（P=0.047）。血清胱抑素C作为慢性肾脏病的标志物，在戒烟后3个月时显著降低。
