Miller Muska, Singer Mervyn
Bloomsbury Institute of Intensive Care Medicine, Cruciform Building, University College London, Gower Street, London, WC1E 6BT, UK.
J Antimicrob Chemother. 2022 Apr 27;77(5):1218-1227. doi: 10.1093/jac/dkac025.
While antibiotics are clearly important treatments for infection, antibiotic-induced modulation of the immune system can have detrimental effects on pathogen clearance and immune functionality, increasing the risk of secondary infection. These injurious consequences may be mediated, at least in part, through effects on the mitochondria, the functioning of which is already compromised by the underlying septic process. Here, we review the complex interactions between antibiotic administration, immune cell and mitochondrial dysfunction.
虽然抗生素显然是治疗感染的重要手段，但抗生素对免疫系统的调节可能会对病原体清除和免疫功能产生不利影响，增加继发感染的风险。这些有害后果可能至少部分是通过对线粒体的影响介导的，而线粒体的功能已经因潜在的脓毒症过程而受损。在此，我们综述抗生素给药、免疫细胞和线粒体功能障碍之间的复杂相互作用。
