Microbiology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.
Microbiology Unit, Department of Biomedical Sciences and Public Health, Polytechnic University of Marche, Ancona, Italy.
Int Rev Cell Mol Biol. 2023;377:121-139. doi: 10.1016/bs.ircmb.2023.03.009. Epub 2023 Apr 10.
Antibiotics are one of the greatest discoveries of medicine of the past century. Despite their invaluable contribution to infectious disease, their administration could lead to side effects that in some cases are serious. The toxicity of some antibiotics is in part due to their interaction with mitochondria: these organelles derive from a bacterial ancestor and possess specific translation machinery that shares similarities with the bacterial counterpart. In other cases, the antibiotics could interfere with mitochondrial functions even if their main bacterial targets are not shared with the eukaryotic cells. The purpose of this review is to summarize the effects of antibiotics administration on mitochondrial homeostasis and the opportunity that some of these molecules could represent in cancer treatment. The importance of antimicrobial therapy is unquestionable, but the identification of interaction with eukaryotic cells and in particular with mitochondria is crucial to reduce the toxicity of these drugs and to explore other useful medical applications.
抗生素是过去一个世纪医学的最伟大发现之一。尽管它们对抗感染疾病有着不可估量的贡献，但它们的使用也可能导致一些严重的副作用。一些抗生素的毒性部分是由于它们与线粒体的相互作用：这些细胞器来源于细菌祖先，拥有与细菌对应物相似的特定翻译机制。在其他情况下，即使抗生素的主要细菌靶标与真核细胞不同，它们也可能干扰线粒体的功能。本文综述的目的是总结抗生素对线粒体动态平衡的影响，以及其中一些分子在癌症治疗中的应用机会。抗菌治疗的重要性是毋庸置疑的，但识别与真核细胞特别是与线粒体的相互作用对于降低这些药物的毒性和探索其他有用的医学应用至关重要。
