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挑战无证据、证据薄弱或证据过时的管理教条:第二部分。

Challenging management dogma where evidence is non-existent, weak, or outdated: part II.

机构信息

Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.

Institute of Intensive Care Medicine, University Hospital Zurich, Zurich, Switzerland.

出版信息

Intensive Care Med. 2024 Nov;50(11):1804-1813. doi: 10.1007/s00134-024-07634-x. Epub 2024 Sep 25.

DOI:10.1007/s00134-024-07634-x
PMID:39320462
Abstract

Many dogmas influence daily clinical practice, and critical care medicine is no exception. We previously highlighted the weak, questionable, and often contrary evidence base underpinning four established medical managements-loop diuretics for acute heart failure, routine use of heparin thromboprophylaxis, rate of sodium correction for hyponatremia, and 'every hour counts' for treating bacterial meningitis. We now provide four further examples in this "Dogma II" piece (a week's course of antibiotics, diabetic ketoacidosis algorithms, sodium bicarbonate to improve ventricular contractility during severe metabolic acidosis, and phosphate replacement for hypophosphatemia) where routine practice warrants re-appraisal.

摘要

许多教条影响着日常的临床实践,重症监护医学也不例外。我们之前曾强调过,四项既定医疗管理措施(急性心力衰竭时使用袢利尿剂、常规使用肝素预防血栓、纠正低钠血症时的钠纠正速度以及治疗细菌性脑膜炎时“每小时都很重要”)的证据基础薄弱、有问题,而且往往相互矛盾。在这篇“教条 II”文章中,我们现在提供了另外四个例子(抗生素治疗一周、糖尿病酮症酸中毒算法、在严重代谢性酸中毒时使用碳酸氢钠改善心室收缩力以及补充低磷血症时的磷酸盐),这些例子表明常规做法需要重新评估。

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Crit Care Med. 2024 Jul 1;52(7):1054-1064. doi: 10.1097/CCM.0000000000006255. Epub 2024 Mar 25.
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Individualised, short-course antibiotic treatment versus usual long-course treatment for ventilator-associated pneumonia (REGARD-VAP): a multicentre, individually randomised, open-label, non-inferiority trial.个体化短疗程抗生素治疗与呼吸机相关性肺炎常规长疗程治疗的比较(REGARD-VAP):一项多中心、个体随机、开放标签、非劣效性试验
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