Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Reprod Sci. 2022 Jul;29(7):1967-1973. doi: 10.1007/s43032-022-00882-6. Epub 2022 Feb 24.
Uterine fibroids (UFs) are the most common pelvic tumor in women. While the decreased quality of life and significant morbidity has been implicated with UFs, several important questions regarding the effect of UFs on reproductive outcomes remain unanswered. Furthermore, there is a disproportionate impact of UFs in Black women, in whom these tumors are known to be more common and more severe. The racial difference in UF burden is heightened during prime reproductive years, during which Black women undergo surgical intervention at an astoundingly increased rate compared to other races. Despite this, Black women are underrepresented in UF and treatment outcome research, and thus the uncertainty of the impact of UFs and UF treatment on fertility and pregnancy outcomes in this population is less defined. The purpose of this review article is to discuss recent findings in the literature regarding the impact of uterine UFs on reproductive outcomes with a primary focus on the implications for Black women. Additionally, we briefly discuss the importance of increased UF research funding and investigation and propose actionable items to help increase the representation of Black women in UF research.
子宫肌瘤（UFs）是女性最常见的盆腔肿瘤。虽然 UFs 已经被认为会降低生活质量并导致严重的发病率，但关于 UFs 对生殖结局影响的几个重要问题仍未得到解答。此外，UFs 在黑人女性中的影响不成比例，这些肿瘤在黑人女性中更为常见且更为严重。在生殖高峰期，UF 负担的种族差异更为明显，在这段时间内，与其他种族相比，黑人女性接受手术干预的比例惊人地增加。尽管如此，黑人女性在 UF 和治疗结果研究中的代表性不足，因此 UF 和 UF 治疗对该人群生育和妊娠结局的影响的不确定性定义不明确。本文综述的目的是讨论文献中关于 UF 对生殖结局影响的最新发现，主要关注其对黑人女性的影响。此外，我们还简要讨论了增加 UF 研究资金和调查的重要性，并提出了一些可行的措施，以帮助增加黑人女性在 UF 研究中的代表性。
