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天然化合物作为溃疡性结肠炎的安全治疗选择。

Natural compounds as safe therapeutic options for ulcerative colitis.

机构信息

School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, 144411, India.

School of Pharmacy and Pharmaceutical Sciences, Ulster University, Coleraine, BT52 1SA, Northern Ireland, UK.

出版信息

Inflammopharmacology. 2022 Apr;30(2):397-434. doi: 10.1007/s10787-022-00931-1. Epub 2022 Feb 25.

DOI:10.1007/s10787-022-00931-1
PMID:35212849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8948151/
Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease of unknown etiology. Several conventional treatments for UC such as corticosteroids, immunosuppressive agents, tumor necrosis factor antagonist, integrin blockers, and interleukin antagonist, and salicylates are available but are associated with the various limitations and side-effects. None of the above treatments helps to achieve the ultimate goal of the therapy, i.e., maintenance of remission in the long-term. Natural remedies for the treatment of UC show comparatively less side effects as compared to conventional approaches, and affordable. The current review presents details on the role of herbal drugs in the treatment and cure of UC. Google, PubMed, Web of Science, and Scopus portals have been searched for potentially relevant literature to get the latest developments and updated information related to use of natural drugs in the treatment of UC. Natural products have been used over centuries to treat UC. Some of the essential herbal constituents exhibiting antiulcerogenic activity include gymnemic acid (Gymnema sylvestre), shagoal (Zingiber officinale), catechin (Camellia sinensis), curcumin (Curcuma longa), arctigenin (Arctium lappa), and boswellic acid (Boswellia serrata). Although many plant-derived products have been recommended for UC, further research to understand the exact molecular mechanism is still warranted to establish their usefulness clinically.

摘要

溃疡性结肠炎（UC）是一种病因不明的慢性炎症性肠病。目前有几种针对 UC 的常规治疗方法，如皮质类固醇、免疫抑制剂、肿瘤坏死因子拮抗剂、整合素阻滞剂、白细胞介素拮抗剂和水杨酸盐，但这些方法都存在各种局限性和副作用。上述治疗方法均无法实现治疗的最终目标，即长期维持缓解。与传统方法相比，用于治疗 UC 的天然疗法的副作用相对较小，且价格合理。本综述介绍了草药在治疗和治愈 UC 中的作用。通过谷歌学术、PubMed、Web of Science 和 Scopus 等数据库搜索了潜在相关文献，以获取与天然药物治疗 UC 相关的最新进展和最新信息。几个世纪以来，人们一直使用天然产物来治疗 UC。一些具有抗溃疡活性的重要草药成分包括匙羹藤酸（Gymnema sylvestre）、姜黄（Zingiber officinale）、儿茶素（Camellia sinensis）、姜黄素（Curcuma longa）、牛蒡子苷元（Arctium lappa）和乳香酸（Boswellia serrata）。尽管有许多植物衍生产品被推荐用于 UC，但仍需要进一步研究以了解确切的分子机制，从而在临床上确定其有效性。

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