氯巴占与驾驶的研究。
Studies of clobazam and car-driving.
作者信息
Biehl B
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):85S-90S. doi: 10.1111/j.1365-2125.1979.tb04671.x.
Abstract
1 The methodology used in studies to assess the effects of drugs on car-driving performance is reviewed. 2 Clobazam 20 mg, diazepam 10 mg or placebo were administered daily for 3 d to 24-male students with a high neuroticism score (on the Cattell Personality Factors Questionnaire). 3 Car driving performance was assessed on the second day in real traffic conditions; tests of attention and concentration and subjective assessments were made on the third day. 4 Diazepam 10 mg significantly impaired braking reaction time in comparison with clobazam 20 mg and placebo (P less than 0.01). Subjects also reported feeling more 'depressed' and lethargic after diazepam.
摘要
- 本文综述了用于评估药物对驾驶性能影响的研究方法。2. 对24名神经质得分较高（基于卡特尔人格因素问卷）的男性学生，每日给予20毫克氯巴占、10毫克地西泮或安慰剂，持续3天。3. 在第二天于实际交通状况下评估驾驶性能；第三天进行注意力和专注力测试以及主观评估。4. 与20毫克氯巴占和安慰剂相比，10毫克地西泮显著损害制动反应时间（P小于0.01）。服用地西泮后，受试者还报告感觉更“沮丧”和无精打采。
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