苯二氮䓬类药物治疗首日的精神运动变化。
Psychomotor changes during initial day of benzodiazepine medication.
作者信息
Wittenborn J R, Flaherty C F, McGough W E, Nash R J
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):69S-76S. doi: 10.1111/j.1365-2125.1979.tb04668.x.
Abstract
1 The detracting psychomotor effects of diazepam (5 mg three times daily) and clobazam (an investigational 1,5-benzodiazepine) were compared with placebo effects over the course of the initial day of medication. Tests were administered at hourly intervals and the data were analyzed from the standpoint of contrasts at each session and from the standpoint of trends that accrued during the course of the day. 2 It is concluded that among normal volunteers diazepam 5 mg three times daily may be near the threshold for detracting psychomotor consequences during the initial day and that clobazam seems to be without detracting consequences and may have some enhancing effects.
摘要
- 在用药首日，将地西泮（每日三次，每次5毫克）和氯巴占（一种研究中的1,5-苯二氮䓬类药物）的减损精神运动效应与安慰剂效应进行了比较。每隔一小时进行一次测试，并从每次测试的对比以及一天中出现的趋势两个角度对数据进行了分析。2. 得出的结论是，在正常志愿者中，每日三次服用5毫克地西泮在用药首日可能接近产生减损精神运动后果的阈值，而氯巴占似乎没有减损后果，可能还有一些增强作用。
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