氯巴占，一种1,5-苯二氮䓬类药物，与驾驶能力。
Clobazam, a 1,5-benzodiazepine, and car-driving ability.
作者信息
Hindmarch I, Hanks G W, Hewett A J
出版信息
Br J Clin Pharmacol. 1977 Oct;4(5):573-8. doi: 10.1111/j.1365-2125.1977.tb00788.x.
Abstract
1 The effects of clobazam, a new anxiolytic agent (a 1,5-benzodiazepine) on car-driving ability and other tests of psychomotor performance were investigated in a double-blind, cross-over study v. placebo in normal volunteers. 2 Clobazam (20 mg) or placebo was given nightly for six nights to ten volunteers and subjective ratings of sleep and subjective and objective assessments of behaviour and psychomotor performance on the morning following drug ingestion were recorded. 3 Clobazam significantly improved the subjective ratings of sleep induction and quality of induced sleep. 4 Clobazam did not significantly impair performance in a variety of psychomotor tests and car-driving ability. 5 The validity of the measures used and the relevance of the findings to real life car-driving situations are discussed.
摘要
- 在一项针对正常志愿者的双盲交叉研究中，将新型抗焦虑药氯巴占（一种1,5 - 苯二氮䓬类药物）与安慰剂进行对比，研究其对驾驶能力及其他精神运动性能测试的影响。2. 每晚给10名志愿者服用氯巴占（20毫克）或安慰剂，持续6晚，并记录服药后次日早晨对睡眠的主观评分以及对行为和精神运动性能的主观和客观评估。3. 氯巴占显著改善了睡眠诱导的主观评分和诱导睡眠的质量。4. 氯巴占在各种精神运动测试和驾驶能力方面并未显著损害表现。5. 讨论了所采用测量方法的有效性以及研究结果与实际驾驶情况的相关性。
相似文献
1
Clobazam, a 1,5-benzodiazepine, and car-driving ability.
Br J Clin Pharmacol. 1977 Oct;4(5):573-8. doi: 10.1111/j.1365-2125.1977.tb00788.x.
2
The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability.
Br J Clin Pharmacol. 1980 Aug;10(2):145-50. doi: 10.1111/j.1365-2125.1980.tb01731.x.
3
Studies of clobazam and car-driving.
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):85S-90S. doi: 10.1111/j.1365-2125.1979.tb04671.x.
4
5
The effects of repeated nocturnal doses of clobazam, dipotassium chlorazepate and placebo on subjective ratings of sleep and early morning behaviour and objective measures of arousal, psychomotor performance and anxiety.
Br J Clin Pharmacol. 1979 Oct;8(4):325-9. doi: 10.1111/j.1365-2125.1979.tb04713.x.
6
Nomifensine, clobazam and HOE 8476: effects on aspects of psychomotor performance and cognitive ability.
Eur J Clin Pharmacol. 1982 Oct;23(4):309-13. doi: 10.1007/BF00613611.
7
Clobazam. A 1.5 benzodiazepine derivative: effects upon human psychomotor performance under different levels of task reinforcement.
Arch Int Pharmacodyn Ther. 1978 Apr;232(2):261-8.
8
9
Some aspects of the effects of clobazam on human psychomotor performance.
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):77S-82S. doi: 10.1111/j.1365-2125.1979.tb04669.x.
10
Residual effects of zopiclone and benzodiazepine hypnotics on psychomotor performance related to car driving.
Drugs Exp Clin Res. 1985;11(12):823-9.
引用本文的文献
1
A scoping review of motor vehicle operator performance assessments for benzodiazepine receptor agonists.
Explor Res Clin Soc Pharm. 2024 Nov 9;16:100538. doi: 10.1016/j.rcsop.2024.100538. eCollection 2024 Dec.
2
Effects of benzodiazepines, antidepressants and opioids on driving: a systematic review and meta-analysis of epidemiological and experimental evidence.
Drug Saf. 2011 Feb 1;34(2):125-56. doi: 10.2165/11539050-000000000-00000.
3
Performance tests.
Environ Health Perspect. 1996 Apr;104 Suppl 2(Suppl 2):247-73. doi: 10.1289/ehp.96104s2247.
4
Psychomotor function and psychoactive drugs.
Br J Clin Pharmacol. 1980 Sep;10(3):189-209. doi: 10.1111/j.1365-2125.1980.tb01745.x.
5
Sedative-hypnotics and human performance.
Psychopharmacology (Berl). 1982;76(2):101-13. doi: 10.1007/BF00435262.
6
Clobazam: a review of its pharmacological properties and therapeutic use in anxiety.
Drugs. 1980 Sep;20(3):161-78. doi: 10.2165/00003495-198020030-00001.
7
The effects of clobazam and lorazepam on aspects of psychomotor performance and car handling ability.
Br J Clin Pharmacol. 1980 Aug;10(2):145-50. doi: 10.1111/j.1365-2125.1980.tb01731.x.
8
Effect on postural sway of various benzodiazepine tranquillizers.
Br J Clin Pharmacol. 1985 Jul;20(1):9-16. doi: 10.1111/j.1365-2125.1985.tb02792.x.
9
[Detection of clobazam (Frisium) in biological material (author's transl)].
Z Rechtsmed. 1978 Nov 10;82(2):105-12. doi: 10.1007/BF01855460.
10
Visual analogue scales and drug effects in man.
Br J Clin Pharmacol. 1978 Jul;6(1):3-4. doi: 10.1111/j.1365-2125.1978.tb01673.x.
本文引用的文献
1
COMPARATIVE EFFECT IN HUMAN SUBJECTS OF CHLORDIAZEPOXIDE, DIAZEPAM, AND PLACEBO ON MENTAL AND PHYSICAL PERFORMANCE.
Clin Pharmacol Ther. 1965 Mar-Apr;6:139-45. doi: 10.1002/cpt196562139.
2
Alcohol and amitriptyline effects on skills related to driving behavior.
Science. 1969 Mar 28;163(3874):1467-8. doi: 10.1126/science.163.3874.1467.
3
Effects of nitrazepam, amylobarbitone and placebo on some perceptual, motor and cognitive tasks in normal subjects.
Psychopharmacologia. 1969;14(3):167-77. doi: 10.1007/BF00404214.
4
The residual effects of flurazepam.
Psychopharmacologia. 1973 Sep 28;32(3):223-35. doi: 10.1007/BF00422145.
5
Pharmacological and toxicological properties of clobazam (1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-diketo-3H-1,5-benzodiazepine), a new psychotherapeutic agent.
Arzneimittelforschung. 1973 May;23(5):683-6.
6
The residual effects of N-desmethyldiazepam in patients.
Psychopharmacologia. 1974;38(1):81-90. doi: 10.1007/BF00421290.
7
Effects of four commonly-used tranquillizers on low-speed driving performance tests.
Br Med J. 1972 Dec 9;4(5840):580-4. doi: 10.1136/bmj.4.5840.580.
8
Immediate effects on human performance of a 1,5-genzodiazepine (clobazam) compared with the 1,4-benzodiazepines, chlordiazepoxide hydrochloride and diazepam.
Br J Clin Pharmacol. 1975 Jun;2(3):215-21. doi: 10.1111/j.1365-2125.1975.tb01578.x.
9
A 1,4-benzodiazepine, temazepam (K 3917), its effect on some psychological parameters of sleep and behaviour.
Arzneimittelforschung. 1975 Nov;25(11):1836-9.
10
Psychomotor skills related to driving after intramuscular administration of diazepam and meperidine.
Anesthesiology. 1975 Jun;42(6):685-91. doi: 10.1097/00000542-197506000-00010.
Zotero 插件