Arnall D A, Marker J C, Conlee R K, Winder W W
Am J Physiol. 1986 Jun;250(6 Pt 1):E641-9. doi: 10.1152/ajpendo.1986.250.6.E641.
To determine the possibility of a threshold concentration of plasma epinephrine that stimulates liver glycogenolysis during exercise, adrenodemedullated (ADM) and sham-operated (SHAM) rats were infused with saline or epinephrine at rates that produced plasma concentrations ranging between 0.01 ng/ml (0.06 nM) and 4.3 ng/ml (23.7 nM). During the infusion rats were run on a rodent treadmill for 0, 30, or 60 min at 21 m/min up a 15% grade. Liver glycogen decreased at similar rates in all exercising rats regardless of plasma epinephrine concentration. Epinephrine infusion stimulated significant muscle glycogen depletion in the soleus and red and white vastus lateralis muscles. ADM saline-infused animals exhibited the least muscle glycogen depletion. Blood glucose and lactate in exercising ADM rats increased as the epinephrine infusion concentration increased. During exercise, there was no epinephrine concentration that stimulated liver glycogenolysis more effectively than physiological saline.
为了确定运动期间刺激肝脏糖原分解的血浆肾上腺素阈值浓度的可能性，给去肾上腺髓质（ADM）大鼠和假手术（SHAM）大鼠输注生理盐水或肾上腺素，输注速率使血浆浓度在0.01 ng/ml（0.06 nM）至4.3 ng/ml（23.7 nM）之间。在输注过程中，大鼠在啮齿动物跑步机上以21 m/min的速度、15%的坡度跑0、30或60分钟。无论血浆肾上腺素浓度如何，所有运动大鼠的肝脏糖原均以相似的速率下降。肾上腺素输注刺激比目鱼肌以及红色和白色股外侧肌的肌肉糖原显著消耗。输注生理盐水的ADM动物的肌肉糖原消耗最少。运动的ADM大鼠的血糖和乳酸随着肾上腺素输注浓度的增加而升高。运动期间，没有肾上腺素浓度比生理盐水更有效地刺激肝脏糖原分解。
