Department of Physiotherapy, Isra University, Amman, Jordan.
Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Rome, Italy.
Appl Neuropsychol Adult. 2023;30(5):602-613. doi: 10.1080/23279095.2022.2041418. Epub 2022 Feb 25.
Cognitive deficits are the most common impairments after traumatic brain injury (TBI). It can be linked with poor physical function. Hyperbaric oxygen therapy (HBOT) increases blood flow and oxygen supply to the brain. This review aimed to summarize and evaluate the available literature on the influences of HBOT on cognitive deficits in patients with TBI. PubMed, SCOPUS, PEDro, REHABDATA, MIDLINE, CHINAL, EMBASE, and Web of Science were searched from inception until June 2021. The methodological quality was measured using the physiotherapy evidence database (PEDro) scale. Ten studies met the eligibility criteria. Six studies were randomized controlled trials, and four were pilot studies. The scores on the PEDro scale ranged from two to nine, with a median score of seven. The included studies showed heterogeneity results for the beneficial effects of HBOT on improving cognitive functions in patients with TBI. The evidence for the beneficial effects of HBOT on cognitive functions post-TBI was limited. Further randomized controlled trials with large sample sizes are strongly needed to understand the effects of HBOT on cognitive functions in patients with TBI.
认知障碍是颅脑外伤（TBI）后最常见的损伤。它可能与身体功能不良有关。高压氧治疗（HBOT）可增加大脑的血流量和氧气供应。本综述旨在总结和评估现有的关于 HBOT 对 TBI 患者认知障碍影响的文献。从开始到 2021 年 6 月，在 PubMed、SCOPUS、PEDro、REHABDATA、MIDLINE、CHINAL、EMBASE 和 Web of Science 上进行了检索。使用物理治疗证据数据库（PEDro）量表来衡量方法学质量。有 10 项研究符合入选标准。其中 6 项为随机对照试验，4 项为试点研究。PEDro 量表的评分范围为 2 至 9 分，中位数为 7 分。纳入的研究显示 HBOT 对改善 TBI 患者认知功能的有益效果存在异质性结果。HBOT 对 TBI 后认知功能有益效果的证据有限。需要进一步开展具有大样本量的随机对照试验，以了解 HBOT 对 TBI 患者认知功能的影响。
