Levi M I
Antibiot Med Biotekhnol. 1986 Mar;31(3):203-9.
The group of high affinity antibodies is advantageous in antigen binding because of different dissociation rates of the antigen-antibody complexes. An antigen interacts with such a group in accordance with the value of the parameters characterizing the group and the antigen. The unbound antigen interacts with the subsequent group by the affinity value and so on. This is the basis of the presented model of univalent antigen interaction with antibodies of different affinity. The model values of the concentration of the bound and free antigens were close to the experimental ones for hyperimmune antiplague horse serum and monoclonal antibodies. The correspondence of the model values to the experimental ones is in favour of the suggested explanation of antigen interaction with antibodies of different affinity. It is advisable that the results be taken into account in estimation of biotechnological possibilities of the preparation of high affinity antibodies.
高亲和力抗体组在抗原结合方面具有优势，这是由于抗原 - 抗体复合物的解离速率不同。抗原根据表征该抗体组和抗原的参数值与这样一组抗体相互作用。未结合的抗原以亲和力值与后续的抗体组相互作用，依此类推。这就是所提出的单价抗原与不同亲和力抗体相互作用模型的基础。对于超免疫抗鼠疫马血清和单克隆抗体，结合抗原和游离抗原浓度的模型值与实验值接近。模型值与实验值的一致性支持了关于抗原与不同亲和力抗体相互作用的所提出的解释。在评估制备高亲和力抗体的生物技术可能性时考虑这些结果是可取的。
