儿科结核病研究与开发：进展、优先事项及资金机会
Pediatric Tuberculosis Research and Development: Progress, Priorities and Funding Opportunities.
作者信息
McKenna Lindsay, Sari Ani Herna, Mane Sushant, Scardigli Anna, Brigden Grania, Rouzier Vanessa, Becerra Mercedes C, Hesseling Anneke C, Amanullah Farhana
机构信息
Treatment Action Group, TB Project, New York, NY 10004, USA.
Global TB Community Advisory Board (TB CAB), Social Science Student at Airlangga University, Surabaya 60286, Indonesia.
出版信息
Pathogens. 2022 Jan 21;11(2):128. doi: 10.3390/pathogens11020128.
Abstract
In this article, we highlight technological pediatric TB research advances across the TB care cascade; discuss recently completed or ongoing work in adults and corresponding significant research gaps for children; and offer recommendations and opportunities to increase investments and accelerate pediatric TB R&D.
摘要
在本文中，我们重点介绍了结核病防治全流程中儿科结核病研究的技术进展；讨论了成人领域近期已完成或正在进行的工作以及儿童领域相应的重大研究空白；并提出了增加投资和加速儿科结核病研发的建议与机会。
相似文献
1
Pediatric Tuberculosis Research and Development: Progress, Priorities and Funding Opportunities.
Pathogens. 2022 Jan 21;11(2):128. doi: 10.3390/pathogens11020128.
2
Investments in tuberculosis research - what are the gaps?
BMC Med. 2016 Aug 25;14(1):123. doi: 10.1186/s12916-016-0644-0.
3
What is operational research and how can national tuberculosis programmes in low- and middle-income countries use it to end TB?
Indian J Tuberc. 2020 Dec;67(4S):S23-S32. doi: 10.1016/j.ijtb.2020.11.009. Epub 2020 Nov 23.
4
Drug-resistant tuberculosis in the European Union: opportunities and challenges for control.
Tuberculosis (Edinb). 2010 May;90(3):182-7. doi: 10.1016/j.tube.2010.03.008. Epub 2010 Apr 10.
6
Updates in Pediatric Tuberculosis in International Settings.
Pediatr Clin North Am. 2022 Feb;69(1):19-45. doi: 10.1016/j.pcl.2021.09.004.
7
Are scientific research outputs aligned with national policy makers' priorities? A case study of tuberculosis in Cambodia.
Health Policy Plan. 2017 Oct 1;32(suppl_2):i3-i11. doi: 10.1093/heapol/czx041.
8
Large funding inflows, limited local capacity and emerging disease control priorities: a situational assessment of tuberculosis control in Myanmar.
Health Policy Plan. 2017 Oct 1;32(suppl_2):i22-i31. doi: 10.1093/heapol/czx062.
9
Pediatric drug-resistant tuberculosis: a global perspective: a global perspective.
Paediatr Drugs. 2011 Dec 1;13(6):349-55. doi: 10.2165/11593160-000000000-00000.
10
Improving diagnosis and case management of patients with tuberculosis: A review of gaps, needs and potential solutions in accessing laboratory diagnostics.
Infect Genet Evol. 2019 Aug;72:131-140. doi: 10.1016/j.meegid.2018.08.030. Epub 2018 Oct 13.
引用本文的文献
1
Barriers and facilitators to pediatric tuberculosis management in India: a systematic review.
BMC Infect Dis. 2025 Apr 10;25(1):495. doi: 10.1186/s12879-025-10863-0.
2
Mycobacterium tuberculosis infection and tuberculosis disease in the first decade of life: a South African birth cohort study.
Lancet Child Adolesc Health. 2024 Dec;8(12):891-899. doi: 10.1016/S2352-4642(24)00256-6. Epub 2024 Nov 5.
3
Clinical Features, Adverse Events and Treatment Outcomes of Multidrug/Rifampicin-resistant Tuberculosis in Children and Adolescents: An Eight-year Retrospective Cohort Study in Bandung, Indonesia.
Pediatr Infect Dis J. 2025 Feb 1;44(2):143-150. doi: 10.1097/INF.0000000000004539. Epub 2024 Sep 23.
4
A public health development intervention between acceptability and feasibility: descriptive-interpretive discussion of an example.
Pan Afr Med J. 2024 Apr 2;47:153. doi: 10.11604/pamj.2024.47.153.42486. eCollection 2024.
5
Effect of lactoferrin in oral nutrition supplement (ONS) towards IL-6 and IL-10 in failure to thrive children with infection.
F1000Res. 2023 Dec 19;12:897. doi: 10.12688/f1000research.130176.3. eCollection 2023.
6
Revealing Gaps in Our Understanding of Finding Children With TB and Our Ability to Inform Policy.
Pediatrics. 2023 Apr 1;151(4). doi: 10.1542/peds.2022-059849.
7
Challenges and the Way forward in Diagnosis and Treatment of Tuberculosis Infection.
Trop Med Infect Dis. 2023 Jan 28;8(2):89. doi: 10.3390/tropicalmed8020089.
8
Review of Pediatric Tuberculosis in the Aftermath of COVID-19.
Clin Pract. 2022 Sep 11;12(5):738-754. doi: 10.3390/clinpract12050077.
9
Pediatric Tuberculosis Management: A Global Challenge or Breakthrough?
Children (Basel). 2022 Jul 27;9(8):1120. doi: 10.3390/children9081120.
10
Tuberculosis in Children and Adolescents: Progress and Perseverance.
Pathogens. 2022 Mar 24;11(4):392. doi: 10.3390/pathogens11040392.
本文引用的文献
1
Screening tests for active pulmonary tuberculosis in children.
Cochrane Database Syst Rev. 2021 Jun 28;6(6):CD013693. doi: 10.1002/14651858.CD013693.pub2.
2
Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis.
N Engl J Med. 2021 May 6;384(18):1705-1718. doi: 10.1056/NEJMoa2033400.
3
Safety and feasibility of 1 month of daily rifapentine plus isoniazid to prevent tuberculosis in children and adolescents: a prospective cohort study.
Lancet Child Adolesc Health. 2021 May;5(5):350-356. doi: 10.1016/S2352-4642(21)00052-3. Epub 2021 Mar 24.
4
Xpert Ultra versus Xpert MTB/RIF for pulmonary tuberculosis and rifampicin resistance in adults with presumptive pulmonary tuberculosis.
Cochrane Database Syst Rev. 2021 Feb 22;2:CD009593. doi: 10.1002/14651858.CD009593.pub5.
5
BCG-induced non-specific effects on heterologous infectious disease in Ugandan neonates: an investigator-blind randomised controlled trial.
Lancet Infect Dis. 2021 Jul;21(7):993-1003. doi: 10.1016/S1473-3099(20)30653-8. Epub 2021 Feb 17.
6
Accuracy of a Novel Urine Test, Fujifilm SILVAMP Tuberculosis Lipoarabinomannan, for the Diagnosis of Pulmonary Tuberculosis in Children.
Clin Infect Dis. 2021 May 4;72(9):e280-e288. doi: 10.1093/cid/ciaa1052.
7
Point-Of-Care Urine LAM Tests for Tuberculosis Diagnosis: A Status Update.
J Clin Med. 2019 Dec 31;9(1):111. doi: 10.3390/jcm9010111.
8
Chest ultrasound compared to chest X-ray for pediatric pulmonary tuberculosis.
Pediatr Pulmonol. 2019 Dec;54(12):1914-1920. doi: 10.1002/ppul.24500. Epub 2019 Sep 1.
9
One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis.
N Engl J Med. 2019 Mar 14;380(11):1001-1011. doi: 10.1056/NEJMoa1806808.
10
Chest ultrasound findings in children with suspected pulmonary tuberculosis.
Pediatr Pulmonol. 2019 Apr;54(4):463-470. doi: 10.1002/ppul.24230. Epub 2019 Jan 11.
Zotero 插件